About: The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity

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About: The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The nuclear SMN complex localizes to specific structures called nuclear gems. The loss of gems is a cellular marker for several neurodegenerative diseases. Here, we identify that the U1-snRNP-specific protein U1-70K localizes to nuclear gems, and we show that U1-70K is necessary for gem integrity. Furthermore, we show that the interaction between U1-70K and the SMN complex is RNA independent, and we map the SMN complex binding site to the unstructured N-terminal tail of U1-70K. Consistent with these results, the expression of the U1-70K N-terminal tail rescues gem formation. These findings show that U1-70K is an SMN-complex-associating protein, and they suggest a new function for U1-70K in the formation of nuclear gems. The nuclear SMN complex localizes to specific structures called nuclear gems. The loss of gems is a cellular marker for several neurodegenerative diseases. Here, we identify that the U1-snRNP-specific protein U1-70K localizes to nuclear gems, and we show that U1-70K is necessary for gem integrity. Furthermore, we show that the interaction between U1-70K and the SMN complex is RNA independent, and we map the SMN complex binding site to the unstructured N-terminal tail of U1-70K. Consistent with these results, the expression of the U1-70K N-terminal tail rescues gem formation. These findings show that U1-70K is an SMN-complex-associating protein, and they suggest a new function for U1-70K in the formation of nuclear gems. (en)
Title	The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity (en)
skos:prefLabel	The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity (en)
skos:notation	RIV/68378050:_____/14:00431703!RIV15-GA0-68378050
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP302/11/1910)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Staněk, David Stejskalová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	46664
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/14:00431703
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nuclear gems; SMN; U1-70K (en)
http://linked.open.../riv/klicoveSlovo	SMN U1-70K nuclear gems
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[82127FD7E30B]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Formation of splicing machinery in the context of the cell nucleus
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	127
http://linked.open...iv/tvurceVysledku	Stejskalová, Eva Staněk, David
http://linked.open...ain/vavai/riv/wos	000342357900005
issn	0021-9533
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1242/jcs.155838

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