About: Feasibility and constraints of particle targeting using the antigen

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About: Feasibility and constraints of particle targeting using the antigen – antibody interaction Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work is concerned with the surface modification of fluorescent silica nanoparticles by a monoclonal antibody (M75) and the specific bioadhesion of such particles to surfaces containing the PG domain of carbonic anhydrase IX (CA IX), which is a trans-membrane protein specifically expressed on the surfaces of several tumor cell lines. The adhesion strength of antibody-bearing silica nanoparticles to antigen- bearing surfaces was investigated under laminar flow conditions in a microfluidic cell and compared to the adhesion of unmodified silica nanoparticles and nanoparticles coupled with an unspecific antibody. Adhesion to cancer cells using flow cytometry was also investigated and in all cases the adhesion strength of M75-modified nanoparticles was significantly stronger than for the unmodified or unspecific nanoparticles, up to several orders of magnitude in some cases. The specific modification of nano- and microparticles by an antibody-like protein therefore appears to be a feasible approach for the targeting of tumor cells. This work is concerned with the surface modification of fluorescent silica nanoparticles by a monoclonal antibody (M75) and the specific bioadhesion of such particles to surfaces containing the PG domain of carbonic anhydrase IX (CA IX), which is a trans-membrane protein specifically expressed on the surfaces of several tumor cell lines. The adhesion strength of antibody-bearing silica nanoparticles to antigen- bearing surfaces was investigated under laminar flow conditions in a microfluidic cell and compared to the adhesion of unmodified silica nanoparticles and nanoparticles coupled with an unspecific antibody. Adhesion to cancer cells using flow cytometry was also investigated and in all cases the adhesion strength of M75-modified nanoparticles was significantly stronger than for the unmodified or unspecific nanoparticles, up to several orders of magnitude in some cases. The specific modification of nano- and microparticles by an antibody-like protein therefore appears to be a feasible approach for the targeting of tumor cells. (en)
Title	Feasibility and constraints of particle targeting using the antigen – antibody interaction Feasibility and constraints of particle targeting using the antigen – antibody interaction (en)
skos:prefLabel	Feasibility and constraints of particle targeting using the antigen – antibody interaction Feasibility and constraints of particle targeting using the antigen – antibody interaction (en)
skos:notation	RIV/68378050:_____/13:00423266!RIV14-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GA13-37055S), S
http://linked.open...iv/cisloPeriodika	23
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Řezáčová, Pavlína Král, Vlastimil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	74789
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00423266
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carbonic anhydrase IX; nanoparticles; drug delivery (en)
http://linked.open.../riv/klicoveSlovo	nanoparticles drug delivery carbonic anhydrase IX
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7B7F9E5F45F3]
http://linked.open...i/riv/nazevZdroje	Nanoscale
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Dalkové ovládání adheze a reakčně-difuzních procesů ve strukturovaných mikročásticích
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Král, Vlastimil Řezáčová, Pavlína Štěpánek, F. Pittermannová, A. Tokárová, V.
http://linked.open...ain/vavai/riv/wos	000326982000016
issn	2040-3364
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c3nr04340a

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