About: Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mutation or epigenetic silencing of the transcription factor C/EBP alpha is observed in similar to 10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBP alpha whereby its expression is inversely correlated with C/EBP alpha activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBP alpha mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBP alpha inactivation contributes to the development of leukemia with a distinct LIC phenotype. Mutation or epigenetic silencing of the transcription factor C/EBP alpha is observed in similar to 10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBP alpha whereby its expression is inversely correlated with C/EBP alpha activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBP alpha mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBP alpha inactivation contributes to the development of leukemia with a distinct LIC phenotype. (en)
Title	Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia (en)
skos:prefLabel	Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia (en)
skos:notation	RIV/68378050:_____/13:00422959!RIV14-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(LK21307)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Alberich-Jorda, Meritxell
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	106737
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00422959
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Sox4; C/EBP alpha; acute myeloid leukemia (en)
http://linked.open.../riv/klicoveSlovo	acute myeloid leukemia C/EBP alpha Sox4
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D4000E303901]
http://linked.open...i/riv/nazevZdroje	Cancer Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	21 (xsd:int)
http://linked.open...vavai/riv/projekt	C/EBPg in normal hematopoiesis and acute myeloid leukemia: identification of the molecular mechanisms involved in cellular transformation
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Zhang, H. Zhang, J. Yang, H. Amabile, G. Delwel, R. DiRuscio, A. Tenen, D. G. Ye, M. Alberich-Jorda, Meritxell Bonifer, C. Cammenga, J. Ebralidze, A. Hoogenkamp, M. Lefebvre, V. Levantini, E. Nerlov, C. Saez, B. Scadden, D. T. Staber, P. B. Valk, P. J. Welner, R. S.
http://linked.open...ain/vavai/riv/wos	000327005100006
issn	1535-6108
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ccr.2013.09.018

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 35 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software