About: Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	When a BCR on a mature B cell is engaged by its ligand, the cell becomes activated, and the Ab-mediated immune response can be triggered. The initiation of BCR signaling is orchestrated by kinases of the Src and Syk families. However, the proximal BCR-induced phosphorylation remains incompletely understood. According to a model of sequential activation of kinases, Syk acts downstream of Src family kinases (SFKs). In addition, signaling independent of SFKs and initiated by Syk has been proposed. Both hypotheses lack sufficient evidence from relevant B cell models, mainly because of the redundancy of Src family members and the importance of BCR signaling for B cell development. We addressed this issue by analyzing controlled BCR triggering ex vivo on primary murine B cells and on murine and chicken B cell lines. Chemical and Csk-based genetic inhibitor treatments revealed that SFKs are required for signal initiation and Syk activation. In addition, ligand and anti-BCR Ab-induced signaling differ in their sensitivity to the inhibition of SFKs. The Journal of Immunology, 2013, 190: 1807-1818. When a BCR on a mature B cell is engaged by its ligand, the cell becomes activated, and the Ab-mediated immune response can be triggered. The initiation of BCR signaling is orchestrated by kinases of the Src and Syk families. However, the proximal BCR-induced phosphorylation remains incompletely understood. According to a model of sequential activation of kinases, Syk acts downstream of Src family kinases (SFKs). In addition, signaling independent of SFKs and initiated by Syk has been proposed. Both hypotheses lack sufficient evidence from relevant B cell models, mainly because of the redundancy of Src family members and the importance of BCR signaling for B cell development. We addressed this issue by analyzing controlled BCR triggering ex vivo on primary murine B cells and on murine and chicken B cell lines. Chemical and Csk-based genetic inhibitor treatments revealed that SFKs are required for signal initiation and Syk activation. In addition, ligand and anti-BCR Ab-induced signaling differ in their sensitivity to the inhibition of SFKs. The Journal of Immunology, 2013, 190: 1807-1818. (en)
Title	Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling (en)
skos:prefLabel	Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling (en)
skos:notation	RIV/68378050:_____/13:00398758!RIV14-GA0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP302/12/1712), P(GBP302/12/G101)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Brdička, Tomáš Hořejší, Václav Dráber, Peter Štěpánek, Ondřej Drobek, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	92003
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/13:00398758
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	BCR signaling; Src family kinases; Syk (en)
http://linked.open.../riv/klicoveSlovo	BCR signaling Src family kinases Syk
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F0507CA82B3E]
http://linked.open...i/riv/nazevZdroje	Journal of Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of signaling through leukocyte receptors their role in health and disease. Function of Csk-anchoring proteins SCIMP and PSTPIP2 in leukocyte signaling and inflammation
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	190
http://linked.open...iv/tvurceVysledku	Brdička, Tomáš Hořejší, Václav Dráber, Peter Štěpánek, Ondřej Drobek, Aleš
http://linked.open...ain/vavai/riv/wos	000314825400044
issn	0022-1767
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.4049/jimmunol.1202401

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