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| rdf:type
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| Description
| - Hledání selektivních a účinných protirakovinných léčiv pro všechny neoplastické choroby by mělo poskytnout universálně vhodné látky. Většina užívaných protirakovinných léků je však buď neselektivních nebo ztrácí svoji účinnost vzhledem k neustálým mutacím maligních buněk. Až donedávna byly velmi zanedbávaným cílem pro potenciální protirakovinná léčiva mitochondrie, které se nyní ukazují jako velmi slibné pro budoucí klinické použití. Analogy vitaminu E (VE), ukázané na příkladu alfa-tokoferylsukcinátu, patří do skupiny „mitokanů“ (mitochondriálně cílených protirakovinných léčiv). Jsou selektivní pro maligní buňky, způsobují destabilizaci mitochondrií a potlačují rakovinu v preklinických modelech. Tento přehled je zaměřen na současné porozumění VE analogů se zřetelem na jejich proapoptotickou/protirakovinnou účinnost a připomíná, že jejich vliv na mitochondrie může být znásoben modulací alternativních drah působích paralelně. (cs)
- The search for a selective and efficient anticancer agent for treating all neoplastic disease has yet to deliver a universally suitable compound(s). The majority of established anticancer drugs either are nonselective or lose their efficacy because of the constant mutational changes of malignant cells. Until recently, a largely neglected target for potential anticancer agents was the mitochondrion, showing a considerable promise for future clinical applications. Vitamin E (VE) analogs, epitomized by alpha-tocopheryl succinate, belong to the group of %22mitocans%22 ( mitochondrially targeted anticancer drugs). They are selective for malignant cells, cause destabilization of their mitochondria, and suppress cancer in preclinical models. This review focuses on our current understanding of VE analogs in the context of their proapoptotic/ anticancer efficacy and suggests that their effect on mitochondria may be amplified by modulation of alternative pathways operating in parallel.
- The search for a selective and efficient anticancer agent for treating all neoplastic disease has yet to deliver a universally suitable compound(s). The majority of established anticancer drugs either are nonselective or lose their efficacy because of the constant mutational changes of malignant cells. Until recently, a largely neglected target for potential anticancer agents was the mitochondrion, showing a considerable promise for future clinical applications. Vitamin E (VE) analogs, epitomized by alpha-tocopheryl succinate, belong to the group of %22mitocans%22 ( mitochondrially targeted anticancer drugs). They are selective for malignant cells, cause destabilization of their mitochondria, and suppress cancer in preclinical models. This review focuses on our current understanding of VE analogs in the context of their proapoptotic/ anticancer efficacy and suggests that their effect on mitochondria may be amplified by modulation of alternative pathways operating in parallel. (en)
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| Title
| - Vitamin E analogs, a novel group of %22mitocans,%22 as anticancer agents: The importance of being redox-silent
- Analogy vitaminu E, nová skupina mitokanů, jako protirakovinná léčiva: důležité být redox-neaktivní (cs)
- Vitamin E analogs, a novel group of %22mitocans,%22 as anticancer agents: The importance of being redox-silent (en)
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| skos:prefLabel
| - Vitamin E analogs, a novel group of %22mitocans,%22 as anticancer agents: The importance of being redox-silent
- Analogy vitaminu E, nová skupina mitokanů, jako protirakovinná léčiva: důležité být redox-neaktivní (cs)
- Vitamin E analogs, a novel group of %22mitocans,%22 as anticancer agents: The importance of being redox-silent (en)
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| skos:notation
| - RIV/68378050:_____/07:00096774!RIV08-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - Z(AV0Z50520514), Z(AV0Z50520701)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00096774
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - vitamin E analogs; redox-silence; anticancer drugs (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Neužil, Jiří
- Ralph, S. J.
- Tomasetti, M.
- Dong, L. F.
- Salvatore, B. A.
- Zhao, Y.
- Wu, K.
- Löw, P.
- Wang, X. F.
- Birringer, M.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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