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| Description
| - The so-called mitocans from the vitamin E group of selective anticancer drugs, α-tocopheryl succinate (α-TOS) and its ether analogue α-TEA, triggered apoptosis in proliferating but not arrested endothelial cells. Angiogenic endothelial cells exposed to the vitamin E analogues, unlike their arrested counterparts, readily accumulated ROS by interfering with the mitochondrial redox chain and activating the intrinsic apoptotic pathway. The vitamin E analogues inhibited angiogenesis in vitro as assessed using the „wound-healing“ and „tube-forming“ models. Endothelial cells deficient in mitochondrial DNA were resistant to the vitamin E analogues, both in ROS accumulation and apoptosis induction, maintaining their high angiogenic potential. α-TOS inhibited angiogenesis in a mouse cancer model, as documented by ultrasound imaging. We conclude that vitamin E analogues selectively kill angiogenic endothelial cells, suppressing tumor growth, which has intriguing clinical implications.
- The so-called mitocans from the vitamin E group of selective anticancer drugs, α-tocopheryl succinate (α-TOS) and its ether analogue α-TEA, triggered apoptosis in proliferating but not arrested endothelial cells. Angiogenic endothelial cells exposed to the vitamin E analogues, unlike their arrested counterparts, readily accumulated ROS by interfering with the mitochondrial redox chain and activating the intrinsic apoptotic pathway. The vitamin E analogues inhibited angiogenesis in vitro as assessed using the „wound-healing“ and „tube-forming“ models. Endothelial cells deficient in mitochondrial DNA were resistant to the vitamin E analogues, both in ROS accumulation and apoptosis induction, maintaining their high angiogenic potential. α-TOS inhibited angiogenesis in a mouse cancer model, as documented by ultrasound imaging. We conclude that vitamin E analogues selectively kill angiogenic endothelial cells, suppressing tumor growth, which has intriguing clinical implications. (en)
- Tzv. mitokany α-TOS a jeho etherový analog α-TEA jako selektivní protirakovinné látky ze skupiny vitaminu E spouštěly apoptózu v proliferujících, nikoliv v nedělících se endoteliálních buňkách. Angiogenní endoteliální buňky vystavené analogům vitaminu E snadno akumulovaly ROS zasahováním do mitochondriálních redoxních řetězců a aktivovaly vnitřní apoptotické dráhy, na rozdíl od neproliferujích protějšků. Analogy vitaminu E inhibovaly angiogenezu in vitro, jak bylo stanoveno na modelech „hojení ran“ a „tvoření trubiček“. Endoteliální buňky deficientní v mitochondriální DNA byly rezistentní k analogům vitaminu E, jak při stanovení akumulace ROS tak při stanovení indukce apoptózy, a udržovaly tak svůj vysoký angiogenní potenciál. α-TOS inhiboval angiogenezu v modelu myší rakoviny, což bylo dokumentováno zobrazením ultrazvukem. Uzavíráme, že analogy vitaminu E selektivně zabíjely angiogenní endoteliální buňky a potlačovaly růst nádorů, což má důležité klinické implikace. (cs)
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| Title
| - alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
- alfa-Tokoferylsukcinát inhibuje angiogenezu přerušením parakrinních FGF2- signálních drah (cs)
- alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling (en)
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| skos:prefLabel
| - alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
- alfa-Tokoferylsukcinát inhibuje angiogenezu přerušením parakrinních FGF2- signálních drah (cs)
- alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling (en)
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| skos:notation
| - RIV/68378050:_____/07:00096529!RIV08-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - Z(AV0Z50520514), Z(AV0Z50520701)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00096529
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - mitocans; proliferating endothelial cells; apoptosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Neužil, Jiří
- Dong, L. F.
- Stapelberg, M.
- Swettenham, E.
- Wang, X. F.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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