About: Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice     Goto   Sponge   NotDistinct   Permalink

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Description
  • To determine if human CD3delta/epsilon (hCD3delta/epsilon) could mediate preTCR-mediated DN to DP transition, a human CD3 transgene was employed that encodes full length CD3delta and a truncated but functional form of CD3epsilon. Surprisingly, the transgene restored the defective preTCR function in not only CD3epsilon- but CD3gamma- and CD3gammadelta-deficient mice as well. A possible role for human CD3delta/epsilon heterodimer in the preTCR-mediated DN to DP transition is discussed.
  • To determine if human CD3delta/epsilon (hCD3delta/epsilon) could mediate preTCR-mediated DN to DP transition, a human CD3 transgene was employed that encodes full length CD3delta and a truncated but functional form of CD3epsilon. Surprisingly, the transgene restored the defective preTCR function in not only CD3epsilon- but CD3gamma- and CD3gammadelta-deficient mice as well. A possible role for human CD3delta/epsilon heterodimer in the preTCR-mediated DN to DP transition is discussed. (en)
  • K objasnění toho, zda lidský CD3delta/epsilon (hCD3delta/epsilon) může zprostředkovat vývoj thymocytů z DN do DP stadia byly využity transgenní myši obsahující kompletní CD3delta a zkrácenou ale funkční formu řetězce CD3epsilon. Transgen překvapivě obnovil funkčnost preTCR nejen v myších defektních v CD3epsilon, ale také CD3gamma- and CD3gammadelta-defektních. Je diskutována možná role lidského CD3delta/epsilon heterodimeru ve vývoji thymocytů. (cs)
Title
  • Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice
  • Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice (en)
  • Odlišná úloha myšího a lidského heterodimeru CD3delta/epsilon ve fungování preT buněčného receptoru (preTCR): lidský heterodimer CD3delta/epsilon obnovuje porušenou funkci preTCR u myší defektních v CD3gama a CD3gama/delta (cs)
skos:prefLabel
  • Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice
  • Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice (en)
  • Odlišná úloha myšího a lidského heterodimeru CD3delta/epsilon ve fungování preT buněčného receptoru (preTCR): lidský heterodimer CD3delta/epsilon obnovuje porušenou funkci preTCR u myší defektních v CD3gama a CD3gama/delta (cs)
skos:notation
  • RIV/68378050:_____/06:00043122!RIV07-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 1741;1750
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 471639
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/06:00043122
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CD3; preTCR; receptor signaling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [CC7D9ACCA97C]
http://linked.open...i/riv/nazevZdroje
  • Molecular Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 43
http://linked.open...iv/tvurceVysledku
  • Drbal, Karel
  • Brodeur, J. F.
  • Pan, Q.
  • Vibhuti, P. D.
http://linked.open...n/vavai/riv/zamer
issn
  • 0161-5890
number of pages
is http://linked.open...avai/riv/vysledek of
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