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Description
| - Předpokládá se, že prozánětlivá odpověď a hyperaktivita HPA osy je zahrnuta v patogenesi deprese. Již dříve jsme zjistili, že antidepresiva inhibují v in vitro podmínkách funkci glukokortikoidního receptoru (GR). Zkoumali jsme vliv LPS na imipramin- nebo fluoxetinem indukovanou inhibici GR ovlivněné genové transkripce ve fibroblastech. Výsledky naznačují, že prozánětlivá agens usnadňují antidepresivy indukovanou inhibici funkce GR. (cs)
- It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function.
- It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function. (en)
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Title
| - Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
- Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription (en)
- Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem (cs)
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skos:prefLabel
| - Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
- Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription (en)
- Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem (cs)
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skos:notation
| - RIV/68378050:_____/05:00025555!RIV06-AV0-68378050
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00025555
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - glucocorticoid receptor; antidepressant drugs; interleukin-6 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Holáň, Vladimír
- Zajícová, Alena
- Basta-Kaim, A.
- Budziszewska, B.
- Kubera, M.
- Leskiewicz, M.
- Tetich, M.
- Lasoń, W.
- Jaworska, L.
- Otczyk, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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