About: The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma

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About: The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hledali jsme geny podílející se na transformaci ledvinných blastemových buněk u ptačích nefroblastomů vyvolaných retrovirem MAV2. Gen twist byl identifikován jako časté místo integrace proviru v nádorových buňkách. Domníváme se, že kuřecí nefroblastomy pocházejí z jediné blastemové buňky, v níž retrovirus MAV svou integrací dereguloval specifické kombinace genů regulujícíh proliferaci a diferenciaci. Aktivace exprese genu twist zřejmě přispívá k tvorbě nádorů, jelikož in vivo dochází k pozitivní selekci klonů nádorových buněk obsahujících gen twist hyperaktivovaný sekvencemi MAV2 vloženými do promotoru twist (cs) The genes involved in the transformation of kidney blastema cells were searched for in avian nephroblastomas by the MAV2 retrovirus. The twist gene was identified as a common site of provirus integration in tumor cells. We propose that chicken nephroblastoma originates from a single blastemic cell in which the MAV retrovirus, through its integration, has deregulated specific combinations of genes controlling proliferation and differentiation. The activation of the twist gene expression appears to contribute to tumorigenesis, as there is and in vivo positive selection of tumor cell clones containing the twist gene hyperactivated by MAV2 sequences inserted within the twist promoter The genes involved in the transformation of kidney blastema cells were searched for in avian nephroblastomas by the MAV2 retrovirus. The twist gene was identified as a common site of provirus integration in tumor cells. We propose that chicken nephroblastoma originates from a single blastemic cell in which the MAV retrovirus, through its integration, has deregulated specific combinations of genes controlling proliferation and differentiation. The activation of the twist gene expression appears to contribute to tumorigenesis, as there is and in vivo positive selection of tumor cell clones containing the twist gene hyperactivated by MAV2 sequences inserted within the twist promoter (en)
Title	Gen twist je běžným cílem integrace retrovirů a transkripční deregulace u experimentálních nefroblastomů (cs) The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma (en)
skos:prefLabel	Gen twist je běžným cílem integrace retrovirů a transkripční deregulace u experimentálních nefroblastomů (cs) The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma (en)
skos:notation	RIV/68378050:_____/03:00108982!RIV/2005/AV0/A23005/N
http://linked.open.../vavai/riv/strany	665;673
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/00/0554), P(GV301/98/K042), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Králová, Jarmila Dvořák, Michal Pečenka, Vladimír Karafiát, Vít Pajer, Petr Hořejší, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	631746
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:00108982
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	twist gene; MAV retrovirus; nephroblastoma (en)
http://linked.open.../riv/klicoveSlovo	nephroblastoma MAV retrovirus twist gene
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D714FEBDEE6B]
http://linked.open...i/riv/nazevZdroje	Oncogene
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification of proteins forming functional complexes with v-Myb oncoprotein Acute monoblastic leukaemia: Analysis of molecular mechanisms and possibilities of targeted regulation
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Dvořák, Michal Králová, Jarmila Karafiát, Vít Pečenka, Vladimír Pajer, Petr Hořejší, Zuzana
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0950-9232
number of pages	9 (xsd:int)

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