About: Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases     Goto   Sponge   NotDistinct   Permalink

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Description
  • The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures
  • The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures (en)
  • Monoklonální protilátka 1696, která byla připravena proti proteáze HIV-1, potlačuje katalytickou aktivitu enzymu z obou kmenů HIV-1 i HIV-2. Tato protilátka křížově reaguje s peptidy obsahující N-konec enzymu, který je mezi těmito dvěma kmeny vysoce konzervován. Je popsána krystalová struktura jednořetězcového fragmentu Fv dříve popsaného nekomplexovaného Fab-1696 a struktur scFv-1696 vázaných na protilátku. Jsou pozorovány rozsáhlé konformační změny ve třetí hypervariabilní oblasti těžkého řetězce a rozdíly v relativní orientaci variabilních domén u těchto různých struktur (cs)
Title
  • Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases
  • Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases (en)
  • Struktura jednořetězcového fragmentu Fv, který inhibuje proteázy HIV-1 a HIV-2 (cs)
skos:prefLabel
  • Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases
  • Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases (en)
  • Struktura jednořetězcového fragmentu Fv, který inhibuje proteázy HIV-1 a HIV-2 (cs)
skos:notation
  • RIV/68378050:_____/03:00108977!RIV/2005/AV0/A23005/N
http://linked.open.../vavai/riv/strany
  • 955;957
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GV203/98/K023), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • Part 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 629257
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/03:00108977
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Immunoglobulin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DK - Dánské království
http://linked.open...ontrolniKodProRIV
  • [44D45C17AF54]
http://linked.open...i/riv/nazevZdroje
  • Acta Crystallographica Section D-Biological Crystallography
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Brynda, Jiří
  • Fábry, Milan
  • Řezáčová, Pavlína
  • Sedláček, Juraj
  • Hořejší, Magdalena
  • Bentley, G. A.
  • Lescar, J.
http://linked.open...n/vavai/riv/zamer
issn
  • 0907-4449
number of pages
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