About: An ex vivo model to study v-Myb-induced leukemogenicity.

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About: An ex vivo model to study v-Myb-induced leukemogenicity. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The v-Myb oncoprotein transforms myeloid cells and induces acute monoblastic leukemia in chickens. We found that deletion of v-Myb PEST-like (P1) domain almost eliminates presence of leukemic monoblasts in the peripheral blood but not their accumulation in the bone marrow (BM). Ex vivo experiments used to compare wild type (wt) and .delta.P1 v-Myb BM monoblasts led to the conclusion that leukemia formation requires the growth factor independency and specific adhesion properties induced in monoblasts by wt v-Myb. The v-Myb oncoprotein transforms myeloid cells and induces acute monoblastic leukemia in chickens. We found that deletion of v-Myb PEST-like (P1) domain almost eliminates presence of leukemic monoblasts in the peripheral blood but not their accumulation in the bone marrow (BM). Ex vivo experiments used to compare wild type (wt) and .delta.P1 v-Myb BM monoblasts led to the conclusion that leukemia formation requires the growth factor independency and specific adhesion properties induced in monoblasts by wt v-Myb. (en)
Title	An ex vivo model to study v-Myb-induced leukemogenicity. An ex vivo model to study v-Myb-induced leukemogenicity. (en)
skos:prefLabel	An ex vivo model to study v-Myb-induced leukemogenicity. An ex vivo model to study v-Myb-induced leukemogenicity. (en)
skos:notation	RIV/68378050:_____/01:23010249!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	437;445
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/00/0554), P(GV301/98/K042), P(IPP2052002), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Králová, Jarmila Dvořáková, Marta Dvořák, Michal Karafiát, Vít Bartůněk, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	673000
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010249
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	v-Myb oncoprotein; - PEST domain; - leucine zipper (en)
http://linked.open.../riv/klicoveSlovo	- PEST domain - leucine zipper v-Myb oncoprotein
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[38FA68D463F4]
http://linked.open...i/riv/nazevZdroje	Blood Cells, Molecules, and Diseases
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification of proteins forming functional complexes with v-Myb oncoprotein Complex approach to study on signals transfer in living organisms Acute monoblastic leukaemia: Analysis of molecular mechanisms and possibilities of targeted regulation
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Bartůněk, Petr Dvořák, Michal Králová, Jarmila Karafiát, Vít Dvořáková, Marta
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1079-9796
number of pages	9 (xsd:int)

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