About: Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants     Goto   Sponge   NotDistinct   Permalink

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  • We compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24 h, either with extractable organic matter (EOMs) from airborne particles <2.5 μm (PM2.5) Our results suggested inhibition of formation of B[a]P-induced DNA adducts compared to individual B[a]P, probably attributable to competitive inhibition by other non-genotoxic EOM components.
  • We compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24 h, either with extractable organic matter (EOMs) from airborne particles <2.5 μm (PM2.5) Our results suggested inhibition of formation of B[a]P-induced DNA adducts compared to individual B[a]P, probably attributable to competitive inhibition by other non-genotoxic EOM components. (en)
Title
  • Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
  • Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants (en)
skos:prefLabel
  • Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
  • Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants (en)
skos:notation
  • RIV/68378041:_____/14:00432596!RIV15-GA0-68378041
http://linked.open...avai/riv/aktivita
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  • I, P(GAP503/11/0142)
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  • 3
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  • 18156
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  • RIV/68378041:_____/14:00432596
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  • air pollutin; DNA adducts; complex mixtures (en)
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  • IE - Irsko
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  • [DEAECAD95F58]
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  • Toxicology Letters
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  • 225
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  • Machala, M.
  • Milcová, Alena
  • Schmuczerová, Jana
  • Topinka, Jan
  • Uhlířová, Kateřina
  • Šrám, Radim
  • Líbalová, Helena
  • Krčková, S.
  • Kléma, J.
  • Cigánek, M.
http://linked.open...ain/vavai/riv/wos
  • 000331725400003
issn
  • 0378-4274
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.toxlet.2014.01.028
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