About: Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This is the first comprehensive study of both human and methodological factors influencing 8-oxodG measurement, providing key information for future studies with this important biomarker. Conclusion: ELISA variability is greater than chromatographic assay variability, and cannot determine absolute levels of 8-oxodG. Use of standardized calibrants greatly improves intra-technique agreement and, for the chromatographic assays, importantly allows integration of results for pooled analyses. If 24 h samples are not feasible, creatinine- or SG-adjusted first morning samples are recommended. This is the first comprehensive study of both human and methodological factors influencing 8-oxodG measurement, providing key information for future studies with this important biomarker. Conclusion: ELISA variability is greater than chromatographic assay variability, and cannot determine absolute levels of 8-oxodG. Use of standardized calibrants greatly improves intra-technique agreement and, for the chromatographic assays, importantly allows integration of results for pooled analyses. If 24 h samples are not feasible, creatinine- or SG-adjusted first morning samples are recommended. (en)
Title	Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine (en)
skos:prefLabel	Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine (en)
skos:notation	RIV/68378041:_____/13:00395220!RIV14-GA0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP503/11/0084)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Šrám, Radim Rössner ml., Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	78293
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/13:00395220
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidative stress; biomarkers; 8-oxodG measurements (en)
http://linked.open.../riv/klicoveSlovo	biomarkers 8-oxodG measurements oxidative stress
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2A55A8F4AF45]
http://linked.open...i/riv/nazevZdroje	Antioxidants & Redox Signaling
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	44 (xsd:int)
http://linked.open...vavai/riv/projekt	The effect of polycyclic aromatic hydrocarbons and particulate matter on DNA damage and DNA repair mechanisms in vitro
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Rössner ml., Pavel Šrám, Radim Smith, R. J. Sakai, K. Mistry, V. Koppen, G. Su, Y. Andreoli, R. Barregard, L. Brogerg, K. Cerda, C. Chao, M. R. Cooke, M. S. Cortez, C. Evans, M. D. Farmer, P. B. Gackowski, D. Haghoost, S. Henriksen, T. Hossain, M. B. Hu, CH. W. Kasai, H. Kawai, K. Lam, P. Li, Y. S. Lindh, C. Loft, S. Manini, P. Marczylo, T. Moller, P. Nataf, R. Olinski, R. Orhan, H. Poulsen, H. E. Rozalski, R. Saez, G. T. Santella, R. M. Senduran, N. Sing, R. Siomek, A. Teichert, F. Weimann, A. Wu, K. Y. Yeh, S.
http://linked.open...ain/vavai/riv/wos	000319871200001
issn	1523-0864
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1089/ars.2012.4714

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