About: Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The impact of air pollution on the subjects living in a heavily polluted Ostrava region and in the relatively clean capital city of Prague was investigated. The study was conducted in three sampling periods (winter 2009, summer 2009, winter 2010) differing in the concentrations of major air pollutants. Concentrations of studied air pollutants (benzo[a]pyrene, benzene) were significantly higher in the Ostrava region in all sampling periods. Despite this fact the levels of bulky DNA adducts in peripheral blood lymphocytes were significantly elevated in the Ostrava subjects only in winter 2009. During the other two sampling periods, the levels of bulky DNA adducts were higher in the Prague subjects. Multivariate analyses revealed that exposure to B[a]P and particulate matter < 2.5 µm affected bulky DNA adduct levels in the Ostrava subjects, but not in subjects from Prague. The impact of air pollution on the subjects living in a heavily polluted Ostrava region and in the relatively clean capital city of Prague was investigated. The study was conducted in three sampling periods (winter 2009, summer 2009, winter 2010) differing in the concentrations of major air pollutants. Concentrations of studied air pollutants (benzo[a]pyrene, benzene) were significantly higher in the Ostrava region in all sampling periods. Despite this fact the levels of bulky DNA adducts in peripheral blood lymphocytes were significantly elevated in the Ostrava subjects only in winter 2009. During the other two sampling periods, the levels of bulky DNA adducts were higher in the Prague subjects. Multivariate analyses revealed that exposure to B[a]P and particulate matter < 2.5 µm affected bulky DNA adduct levels in the Ostrava subjects, but not in subjects from Prague. (en)
Title	Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts (en)
skos:prefLabel	Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I. Bulky DNA adducts (en)
skos:notation	RIV/68378041:_____/13:00384430!RIV14-MSM-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(2B08005), P(GAP503/11/0084), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Šrám, Radim Topinka, Jan Milcová, Alena Rössner ml., Pavel Schmuczerová, Jana Švecová, Vlasta Pastorková, Anna Tabashidze, Nana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	60486
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/13:00384430
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Air pollution; biomarkers; DNA adducts (en)
http://linked.open.../riv/klicoveSlovo	DNA adducts biomarkers Air pollution
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3B8E1B2C1AEF]
http://linked.open...i/riv/nazevZdroje	Mutagenesis
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants. The effect of polycyclic aromatic hydrocarbons and particulate matter on DNA damage and DNA repair mechanisms in vitro
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Milcová, Alena Rössner ml., Pavel Schmuczerová, Jana Topinka, Jan Šrám, Radim Švecová, Vlasta Tabashidze, Nana Pastorková, Anna
http://linked.open...ain/vavai/riv/wos	000312888900011
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0267-8357
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/mutage/ges057

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