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Description
| - The aim of this study was to evaluate the targeting of mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles to the site of a spinal cord injury by means of a magnetic implant. We monitored both the distribution and the number of cells in the lesion site after their intrathecal administration and the effect of the magnetic implant on cell transplantation. The cell distribution correlated with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and the lesion site. Our results showed that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. We suggested a mathematical model of cell targeting kinetics and analyzed those parameters of the magnetic system critical for efficient cell targeting.
- The aim of this study was to evaluate the targeting of mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles to the site of a spinal cord injury by means of a magnetic implant. We monitored both the distribution and the number of cells in the lesion site after their intrathecal administration and the effect of the magnetic implant on cell transplantation. The cell distribution correlated with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and the lesion site. Our results showed that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. We suggested a mathematical model of cell targeting kinetics and analyzed those parameters of the magnetic system critical for efficient cell targeting. (en)
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Title
| - Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
- Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury (en)
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skos:prefLabel
| - Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
- Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury (en)
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skos:notation
| - RIV/68378041:_____/12:00383008!RIV13-AV0-68378041
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GAP304/11/0189), P(GAP304/11/0653), P(GAP304/11/0731), P(GAP304/12/1370), P(IAA500390902), V, Z(AV0Z10100522), Z(AV0Z40500505), Z(AV0Z50390703)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378041:_____/12:00383008
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - nanoparticles; mesenchymal stem cells; magnetic targeting (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - International Journal of Nanomedicine
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Dejneka, Alexandr
- Růžička, Jiří
- Syková, Eva
- Kubinová, Šárka
- Herynek, V.
- Jendelová, Pavla
- Zablotskyy, Vitaliy A.
- Vaněček, Václav
- Forostyak, Serhiy
- Babič, Michal
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
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is http://linked.open...avai/riv/vysledek
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