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Description
| - Here we show that polydendrocytes participate in CNS repair following focal cerebral ischemia. We followed their fate after a permanent middle cerebral artery occlusion (MCAo) in adult NG2creBAC:ZEG double transgenic mice, in which enhanced green fluorescent protein (EGFP) is expressed in polydendrocytes and their progeny. We found that 3 days after MCAo the EGFP(+) cells markedly proliferate,. however, in later phases after MCAo they give rise to a subpopulation of reactive astrocytes and moreover, some EGFP(+) cells expressed doublecortin and displayed membrane properties typical for neural precursor cells, Taken together, our data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia.
- Here we show that polydendrocytes participate in CNS repair following focal cerebral ischemia. We followed their fate after a permanent middle cerebral artery occlusion (MCAo) in adult NG2creBAC:ZEG double transgenic mice, in which enhanced green fluorescent protein (EGFP) is expressed in polydendrocytes and their progeny. We found that 3 days after MCAo the EGFP(+) cells markedly proliferate,. however, in later phases after MCAo they give rise to a subpopulation of reactive astrocytes and moreover, some EGFP(+) cells expressed doublecortin and displayed membrane properties typical for neural precursor cells, Taken together, our data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia. (en)
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Title
| - Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia
- Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia (en)
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skos:prefLabel
| - Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia
- Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia (en)
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skos:notation
| - RIV/68378041:_____/12:00379159!RIV13-AV0-68378041
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http://linked.open...avai/predkladatel
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GA305/09/0717), P(GAP303/12/0855), P(GD309/08/H079), Z(AV0Z50390703)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378041:_____/12:00379159
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - NG2 glia; CNS regeneration; patch clamp (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pivoňková, Helena
- Anděrová, Miroslava
- Džamba, Dávid
- Honsa, Pavel
- Filipová, Marcela
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1371/journal.pone.0036816
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is http://linked.open...avai/riv/vysledek
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