About: Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion. Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion. (en)
Title	Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair (en)
skos:prefLabel	Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair (en)
skos:notation	RIV/68378041:_____/11:00368381!RIV12-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GAP304/11/0731), P(GPP304/11/P633), P(IAA500390902), Z(AV0Z40500505), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Syková, Eva Kubinová, Šárka Hejčl, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	202078
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00368381
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	2-hydroxyethyl methacrylate; scaffold; spinal cord repair (en)
http://linked.open.../riv/klicoveSlovo	scaffold 2-hydroxyethyl methacrylate spinal cord repair
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1E70CBBFA557]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Materials Research. Part A
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of stem cells and biomaterials for spinal cord injury repair Center for Cell Therapy and Tissue Repair Spinal cord injury repair using biomodified hydrogels with oriented channels Axonal regeneration across a complete spinal cord lesion bridged with hydrogels seeded with mesenchymal stem cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	99
http://linked.open...iv/tvurceVysledku	Horák, Daniel Kotek, Jiří Syková, Eva Kubinová, Šárka Hejčl, Aleš Plichta, Zdeněk
http://linked.open...ain/vavai/riv/wos	000297019200012
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1549-3296
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jbm.a.33221
is http://linked.open...avai/riv/vysledek of	Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair

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