About: The use of oligoperoxide-coated magnetic nanoparticles to label stem cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Iron oxide nanoparticles obtained by the coprecipitation of Fe(II) and Fe(III) salts and oxidation were coated with a novel poly(vinyl acetate-co-5-tert-(butylperoxy)-5-methylhex-1-en-3-yne-co-butyl acrylate-co-maleic anhydride) (PVBM) oligomer to ensure colloidal stability. The magnetic nanoparticles were thoroughly characterized by a range of physico-chemical methods, which proved the presence of the coating on the particles. Experiments with rat mesenchymal stem cells (rMSCs) confirmed that PVBM-coated γ-Fe2O3 nanoparticles were not cytotoxic and that the average efficiency of stem cell labeling was good and comparable to that obtained with commercial agents. The cells labeled with PVBM-coated γ-Fe2O3 nanoparticles displayed excellent contrast on magnetic resonance (MR) images. Such particles are thus promising for in vivo MR imaging of transplanted cells. Moreover, PVBM offers possibility of additional modification by grafting compounds that reduce non-specific protein adsorption. Iron oxide nanoparticles obtained by the coprecipitation of Fe(II) and Fe(III) salts and oxidation were coated with a novel poly(vinyl acetate-co-5-tert-(butylperoxy)-5-methylhex-1-en-3-yne-co-butyl acrylate-co-maleic anhydride) (PVBM) oligomer to ensure colloidal stability. The magnetic nanoparticles were thoroughly characterized by a range of physico-chemical methods, which proved the presence of the coating on the particles. Experiments with rat mesenchymal stem cells (rMSCs) confirmed that PVBM-coated γ-Fe2O3 nanoparticles were not cytotoxic and that the average efficiency of stem cell labeling was good and comparable to that obtained with commercial agents. The cells labeled with PVBM-coated γ-Fe2O3 nanoparticles displayed excellent contrast on magnetic resonance (MR) images. Such particles are thus promising for in vivo MR imaging of transplanted cells. Moreover, PVBM offers possibility of additional modification by grafting compounds that reduce non-specific protein adsorption. (en)
Title	The use of oligoperoxide-coated magnetic nanoparticles to label stem cells The use of oligoperoxide-coated magnetic nanoparticles to label stem cells (en)
skos:prefLabel	The use of oligoperoxide-coated magnetic nanoparticles to label stem cells The use of oligoperoxide-coated magnetic nanoparticles to label stem cells (en)
skos:notation	RIV/68378041:_____/11:00363241!RIV12-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0538), P(GA203/09/1242), P(GAP503/10/0664), P(KAN201110651), P(KAN401220801), Z(AV0Z40500505), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Syková, Eva Jendelová, Pavla Lesný, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	237244
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00363241
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	magnetic; nanoparticles; stem cells (en)
http://linked.open.../riv/klicoveSlovo	stem cells nanoparticles magnetic
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[534E1E95A4BB]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Nanotechnology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Surface-modified magnetic nanoparticles for cell labeling and in vivo and in vitro diagnostics Center for Cell Therapy and Tissue Repair Nanostructures of Controlled Size and Dimensions Combined contrast agents for molecular MR imaging Isolation, typing and the development of immunochemical and instrumetal methods for detection and characterization of Cronobacter sp.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Horák, Daniel Syková, Eva Trchová, Miroslava Herynek, V. Jendelová, Pavla Mitina, N. Stoika, R. Zaichenko, A. Lesný, Petr Šponarová, Daniela
http://linked.open...ain/vavai/riv/wos	000292858900008
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1550-7033
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1166/jbn.2011.1289
is http://linked.open...avai/riv/vysledek of	The use of oligoperoxide-coated magnetic nanoparticles to label stem cells The use of oligoperoxide-coated magnetic nanoparticles to label stem cells

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