About: Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated associations between the levels of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn’s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2. We investigated associations between the levels of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn’s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2. (en)
Title	Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic (en)
skos:prefLabel	Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic (en)
skos:notation	RIV/68378041:_____/11:00356231!RIV11-MZP-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(SP/1B3/50/07), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šrám, Radim Špátová, Milada Rössner ml., Pavel Nováková, Zuzana Dostál, Miroslav Chvátalová, Irena Tabashidze, Nana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	200983
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00356231
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	air pollution; biomarkers; genetic polymorphisms (en)
http://linked.open.../riv/klicoveSlovo	genetic polymorphisms biomarkers air pollution
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A72E4077DB20]
http://linked.open...i/riv/nazevZdroje	Environmental Health Perspectives
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The influence of genome on the interaction of human organism and environment
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	119
http://linked.open...iv/tvurceVysledku	Nováková, Zuzana Rössner ml., Pavel Šrám, Radim Špátová, Milada Dostál, Miroslav Chvátalová, Irena Tabashidze, Nana
http://linked.open...ain/vavai/riv/wos	000286803400031
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0091-6765
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic

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