About: Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	For human embryonic stem cells (hESC) to be used in cell replacement therapies, they must be grown under good manufacturing conditions in a chemically defined medium that lacks animal proteins. This study examined the ability of a newly designed medium containing the plant-derived serum replacement VegetaCell and other reagents of human origin to support undifferentiated growth and pluripotency of hESC. Even under the most stringent feeder-free conditions without conditioned medium, hESC exhibited an undifferentiated morphology, expressed markers of undifferentiated cells, demonstrated high alkaline phosphatase activity and multilineage differentiation and retained a normal karyotype. For human embryonic stem cells (hESC) to be used in cell replacement therapies, they must be grown under good manufacturing conditions in a chemically defined medium that lacks animal proteins. This study examined the ability of a newly designed medium containing the plant-derived serum replacement VegetaCell and other reagents of human origin to support undifferentiated growth and pluripotency of hESC. Even under the most stringent feeder-free conditions without conditioned medium, hESC exhibited an undifferentiated morphology, expressed markers of undifferentiated cells, demonstrated high alkaline phosphatase activity and multilineage differentiation and retained a normal karyotype. (en)
Title	Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells (en)
skos:prefLabel	Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells (en)
skos:notation	RIV/68378041:_____/10:00350113!RIV11-AV0-68378041
http://linked.open...avai/riv/aktivita	I R Z
http://linked.open...avai/riv/aktivity	I, R, Z(AV0Z50390512), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hampl, Aleš Dvořák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	253954
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00350113
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	animal protein-free culture; high-density culture; human embryonic stem cells (en)
http://linked.open.../riv/klicoveSlovo	animal protein-free culture high-density culture human embryonic stem cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E9694467B038]
http://linked.open...i/riv/nazevZdroje	Reproductive BioMedicine Online
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Dvořák, Petr Hampl, Aleš Matulka, K. Eiselleová, L. Kunová, M. Trčková, P.
http://linked.open...ain/vavai/riv/wos	000284797000016
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1472-6483
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells Development of humanized culture medium with plant-derived serum replacement for human pluripotent stem cells

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