About: Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Pairwise tagging was used to select the 11 polymorphisms and the selected polymorphisms were genotyped in cases and controls from the Czech Republic and further verified on the German population. T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004). Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Pairwise tagging was used to select the 11 polymorphisms and the selected polymorphisms were genotyped in cases and controls from the Czech Republic and further verified on the German population. T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004). (en)
Title	Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study (en)
skos:prefLabel	Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study (en)
skos:notation	RIV/68378041:_____/10:00349610!RIV11-GA0-68378041
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA310/05/2626), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vodičková, Ludmila Vodička, Pavel Naccarati, Alessio Pardini, Barbara
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	279798
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00349610
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; insulin; GHSR (en)
http://linked.open.../riv/klicoveSlovo	colorectal cancer insulin GHSR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3E8636521FB1]
http://linked.open...i/riv/nazevZdroje	BMC Gastroenterology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	22 (xsd:int)
http://linked.open...vavai/riv/projekt	Case-control study on colorectal carcinoma: genetic profiling of xenobiotic metabolising and DNA repair enzymes
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Barale, R. Betz, B. Büttner, R. Campa, D. Canzian, F. Engel, C. Försti, A. Görgens, H. Hemminki, K. Holinski-Feder, E. Kloor, M. Morak, M. Naccarati, Alessio Novotný, J. Pardini, Barbara Propping, P. Rahner, N. Schackert, H. K. Steinke, V. Vodička, Pavel Vodičková, Ludmila Kötting, J.
http://linked.open...ain/vavai/riv/wos	000282779500001
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1471-230X
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

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