About: An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The genotoxicity of the organic extracts (EOMs) from three size fractions of aerosols (ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) was compared using the analysis of total DNA adducts induced in an acellular assay with/without metabolic activation. It was found that most of the observed genotoxicity was connected with a fine particulate matter fraction (<1µm). These fine fractions bound the highest amount of c-PAHs in all aerosol sites, which might be related to their higher specific surface. As for aerosol mass, both fine and condensational fractions are effective carriers of c-PAHs. Similarly, the DNA adduct levels per m3 of air were highest for the fine fraction and a strong correlation was found between the c-PAHs and DNA adduct levels induced by EOMs in all the localities and for various size fractions. The genotoxicity of the organic extracts (EOMs) from three size fractions of aerosols (ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) was compared using the analysis of total DNA adducts induced in an acellular assay with/without metabolic activation. It was found that most of the observed genotoxicity was connected with a fine particulate matter fraction (<1µm). These fine fractions bound the highest amount of c-PAHs in all aerosol sites, which might be related to their higher specific surface. As for aerosol mass, both fine and condensational fractions are effective carriers of c-PAHs. Similarly, the DNA adduct levels per m3 of air were highest for the fine fraction and a strong correlation was found between the c-PAHs and DNA adduct levels induced by EOMs in all the localities and for various size fractions. (en)
Title	An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts (en)
skos:prefLabel	An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts (en)
skos:notation	RIV/68378041:_____/10:00347664!RIV11-MSM-68378041
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08005), P(SP/1A3/149/08), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šrám, Radim Topinka, Jan Milcová, Alena Rössner ml., Pavel Schmuczerová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	246136
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00347664
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Air pollution; Complex mixtures; DNA adducts (en)
http://linked.open.../riv/klicoveSlovo	DNA adducts Air pollution Complex mixtures
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[FE578FA9E4BD]
http://linked.open...i/riv/nazevZdroje	Toxicology Letters
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants. Highly time- and size-resolved concentrations of atmospheric aerosol and its constituents for resolution its sources and genotoxicity
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	198
http://linked.open...iv/tvurceVysledku	Milcová, Alena Rössner ml., Pavel Schmuczerová, Jana Topinka, Jan Šrám, Radim Hovorka, J. Kroužek, J.
http://linked.open...ain/vavai/riv/wos	000282855300002
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0378-4274
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts

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