About: An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The study investigated the ability of organic extracts of size segregated aerosol particles-PM (EOM; three size fractions ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) to induce oxidative damage to DNA in an acellular system of calf thymus DNA with/without metabolic activation. It was found that levels of 8-oxodG tended to increase with decreasing sizes of PM; metabolic activation increased the oxidative capacity of PM. A significant positive association between concentrations of c-PAHs bound to PM and levels of 8-oxodG after metabolic activation of EOM samples was observed. The correlation was weaker and non-significant for samples without metabolic activation. It may be concluded that organic extracts of PM were able to induce oxidative damage to DNA in vitro; this ability was increased after S9 metabolic activation of EOM and with decreasing sizes of PM. The study investigated the ability of organic extracts of size segregated aerosol particles-PM (EOM; three size fractions ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) to induce oxidative damage to DNA in an acellular system of calf thymus DNA with/without metabolic activation. It was found that levels of 8-oxodG tended to increase with decreasing sizes of PM; metabolic activation increased the oxidative capacity of PM. A significant positive association between concentrations of c-PAHs bound to PM and levels of 8-oxodG after metabolic activation of EOM samples was observed. The correlation was weaker and non-significant for samples without metabolic activation. It may be concluded that organic extracts of PM were able to induce oxidative damage to DNA in vitro; this ability was increased after S9 metabolic activation of EOM and with decreasing sizes of PM. (en)
Title	An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA (en)
skos:prefLabel	An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA (en)
skos:notation	RIV/68378041:_____/10:00347658!RIV11-MSM-68378041
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08005), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šrám, Radim Topinka, Jan Milcová, Alena Rössner ml., Pavel Schmuczerová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	246137
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00347658
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	air pollution; particulate matter; atmospheric aerosol (en)
http://linked.open.../riv/klicoveSlovo	atmospheric aerosol particulate matter air pollution
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[AFAAFCFAE426]
http://linked.open...i/riv/nazevZdroje	Toxicology Letters
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	198
http://linked.open...iv/tvurceVysledku	Milcová, Alena Rössner ml., Pavel Schmuczerová, Jana Topinka, Jan Šrám, Radim Hovorka, J. Kroužek, J.
http://linked.open...ain/vavai/riv/wos	000282855300003
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0378-4274
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA

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