About: Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The role of oxidative damage in the mechanisms of action of selected individual c-PAHs, an artificial mixture of c-PAHs and extractable organic matter (EOM) from urban air particulate matter was investigated using two cell lines (HepG2 and HEL). The response of the cell lines to the tested compounds differed substantially. The study demonstrated the potency of EOM to induce oxidative damage to DNA, lipids and proteins in HepG2 cells, but not in HEL cels. The analysis also showed that c-PAHs had less ability to cause oxidative damage. The role of oxidative damage in the mechanisms of action of selected individual c-PAHs, an artificial mixture of c-PAHs and extractable organic matter (EOM) from urban air particulate matter was investigated using two cell lines (HepG2 and HEL). The response of the cell lines to the tested compounds differed substantially. The study demonstrated the potency of EOM to induce oxidative damage to DNA, lipids and proteins in HepG2 cells, but not in HEL cels. The analysis also showed that c-PAHs had less ability to cause oxidative damage. (en)
Title	Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter (en)
skos:prefLabel	Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter (en)
skos:notation	RIV/68378041:_____/10:00340206!RIV10-MSM-68378041
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08005), P(SP/1B3/8/08), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šrám, Radim Rössner ml., Pavel Uhlířová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	277873
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00340206
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carcinogenic polycyclic aromatic hydrocarbons; oxidative damage in vitro; extractable organic matter (en)
http://linked.open.../riv/klicoveSlovo	carcinogenic polycyclic aromatic hydrocarbons extractable organic matter oxidative damage in vitro
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[357A5034F6AF]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	The impact of air pollution to human health in the Ostrava region using genomic methods - AIRGEN New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	696
http://linked.open...iv/tvurceVysledku	Rössner ml., Pavel Šrám, Radim Hanzalová, Kateřina
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1383-5718
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Oxidative damage by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter

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