About: P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical dissociation. The main properties of the ATP-induced response in cortical astrocytes (high sensitivity to ATP, biphasic kinetics, and sensitivity to PPADS) were very similar to those reported for P2X(1/5) heteromeric receptors studied previously in heterologous expression systems. ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical dissociation. The main properties of the ATP-induced response in cortical astrocytes (high sensitivity to ATP, biphasic kinetics, and sensitivity to PPADS) were very similar to those reported for P2X(1/5) heteromeric receptors studied previously in heterologous expression systems. (en) ATP hraje významnou úlohu v přenosu signálů mezi neuronálními a gliálními systémy a uvnitř gliálních sítí. Studovali jsme proudy vyvolané pomocí ATP v astrocytech akutně izolovaných z mozkových řezů ne-enzymatickou mechanickou disociací. Prokázali jsme, že hlavní vlastnosti odpovědí vyvolané ATP v korových astrocytech, t.j. vysoká citlivost k ATP, dvojfázová kinetika, senzitivita k PPADS, je velice podobná vlastnostem popsaným u P2X(1/5) heteromérních receptorů, studovyných u heterologních expresních systémů. (cs)
Title	P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes P2X1 a P2X5 podjednotky vytvářejí funkční P2X receptor v korových astrocytech u myší (cs) P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes (en)
skos:prefLabel	P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes P2X1 a P2X5 podjednotky vytvářejí funkční P2X receptor v korových astrocytech u myší (cs) P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes (en)
skos:notation	RIV/68378041:_____/08:00317730!RIV09-AV0-68378041
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Verkhratsky, Alexei
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	391140
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/08:00317730
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	P2X1/5; Receptors; GFAP–EGFP mice (en)
http://linked.open.../riv/klicoveSlovo	Receptors GFAP–EGFP mice P2X1/5
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[72B85CBFAF7F]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Lalo, U. North, R. A. Pankratov, Y. Verkhratsky, Alexei Kirchhoff, F. Rossner, M. J. Wichert, S. P.
http://linked.open...ain/vavai/riv/wos	256066200009
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0270-6474
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes

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