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  • Poškození nejen Ca2+ homeostázy v neuronech, ale i mitochondriální funkce, byly prokázány u mnoha chorob CNS a PNS, včetně diabetické senzorové neuropatie. Endoplasmatické retikulum částečně reguluje buněčnou Ca2+ homeostázu a tento proces je přímo spojen s regulací mitochondriální funkce a aktivity anti-apoptotických signálů. Předpokládáme, že nedostatek neurotrofních faktorů, zvláště ve vztahu ke snížené expresi insulínu a neurotrofínu-3 vyvolaných diabetem, má za následek alterace ve fenotypu senzorových neuronů, které jsou kritické pro vznik abnormální Ca2+ homeostázy a asociované mitochondriální disfunkce. (cs)
  • Abnormal neuronal Ca(2+) homeostasis and impaired mitochondrial function have been implicated in numerous CNS and PNS diseases including diabetic sensory neuropathy. The endoplasmic reticulum, in part, regulates cellular Ca(2+) homeostasis and this process is linked to regulation of mitochondrial function and activity of anti-apoptotic signal transduction pathways. We hypothesize that deficits in neurotrophic factor support, specifically linked to diabetes-induced lowered expression of insulin and neurotrophin-3, triggers alterations of sensory neurone phenotype that are critical for the development of abnormal Ca(2+) homeostasis and associated mitochondrial dysfunction.
  • Abnormal neuronal Ca(2+) homeostasis and impaired mitochondrial function have been implicated in numerous CNS and PNS diseases including diabetic sensory neuropathy. The endoplasmic reticulum, in part, regulates cellular Ca(2+) homeostasis and this process is linked to regulation of mitochondrial function and activity of anti-apoptotic signal transduction pathways. We hypothesize that deficits in neurotrophic factor support, specifically linked to diabetes-induced lowered expression of insulin and neurotrophin-3, triggers alterations of sensory neurone phenotype that are critical for the development of abnormal Ca(2+) homeostasis and associated mitochondrial dysfunction. (en)
Title
  • Mitochondrial malfunction and Ca(2+) dyshomeostasis drive neuronal pathology in diabetes
  • Mitochondrial malfunction and Ca(2+) dyshomeostasis drive neuronal pathology in diabetes (en)
  • Narušení funkce mitochondrií a homeostázy Ca2+ vyvolává patologii neuronů v průběhu diabetu (cs)
skos:prefLabel
  • Mitochondrial malfunction and Ca(2+) dyshomeostasis drive neuronal pathology in diabetes
  • Mitochondrial malfunction and Ca(2+) dyshomeostasis drive neuronal pathology in diabetes (en)
  • Narušení funkce mitochondrií a homeostázy Ca2+ vyvolává patologii neuronů v průběhu diabetu (cs)
skos:notation
  • RIV/68378041:_____/08:00317696!RIV09-AV0-68378041
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Verkhratsky, Alexei
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 379648
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/08:00317696
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Dorsal root ganglia; Mitochondria; Neurotrophic factors (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [F4728A13B01B]
http://linked.open...i/riv/nazevZdroje
  • Cell Calcium
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 44
http://linked.open...iv/tvurceVysledku
  • Verkhratsky, Alexei
  • Fernyhough, P.
http://linked.open...ain/vavai/riv/wos
  • 257656400011
http://linked.open...n/vavai/riv/zamer
issn
  • 0143-4160
number of pages
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