About: A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer     Goto   Sponge   NotDistinct   Permalink

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  • ATP-binding cassette (ABC) transporters actively export a wide variety of molecules from cells, contributing to reduce the local cellular burden of toxic compounds. ABCG2/BCRP is abundantly expressed in epithelial cells of the intestine and colon. Thus, we found no strong and clearcut association between ABCG2 polymorphisms and CRC risk. To our knowledge this is the first report on ABCG2 and CRC risk.
  • ATP-binding cassette (ABC) transporters actively export a wide variety of molecules from cells, contributing to reduce the local cellular burden of toxic compounds. ABCG2/BCRP is abundantly expressed in epithelial cells of the intestine and colon. Thus, we found no strong and clearcut association between ABCG2 polymorphisms and CRC risk. To our knowledge this is the first report on ABCG2 and CRC risk. (en)
  • ATP vazebný transporter aktivně exportuje širokou škálu molekul z buňky a přispívá k redukci lokálního výskytu toxických sloučenin. ABCG2/BCRP je hojně exprimován v epiteliálních buňkách v tlustém střevě. Selektovaly jsme 15 polymorfizmů, které pokrývají celou známou oblast genetických variací genu u 680 pacientů s kolorektálním karcinomem a 593 kontrolních jedinců. V naší studii jsme nezaznamenali žádne signifikantní riziko vzniku CRC ve vztahu k polymoprfizmu ABCG/BRCP genu. Toto je první studie zabývající se vztahem ABCG2 a rizikem vzniku CRC. (cs)
Title
  • A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer
  • Celogenní vyšetření polymorfizmu v ABCG2/BRCP transportery a vnímovast ke kolorektálnímu karcinomu (cs)
  • A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer (en)
skos:prefLabel
  • A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer
  • Celogenní vyšetření polymorfizmu v ABCG2/BRCP transportery a vnímovast ke kolorektálnímu karcinomu (cs)
  • A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer (en)
skos:notation
  • RIV/68378041:_____/08:00313805!RIV09-AV0-68378041
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA310/07/1430), Z(AV0Z50390512), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 354206
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/08:00313805
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ABCG2; Transporter; Colorectal cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [94DE3877005A]
http://linked.open...i/riv/nazevZdroje
  • Mutation Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 645
http://linked.open...iv/tvurceVysledku
  • Barale, R.
  • Campa, D.
  • Canzian, F.
  • Försti, A.
  • Hemminki, K.
  • Naccarati, Alessio
  • Novotný, J.
  • Pardini, Barbara
  • Vodička, Pavel
  • Vodičková, Ludmila
http://linked.open...ain/vavai/riv/wos
  • 260979200008
http://linked.open...n/vavai/riv/zamer
issn
  • 0027-5107
number of pages
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