About: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3     Goto   Sponge   NotDistinct   Permalink

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Description
  • To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1 we genotyped 550 163 tagSNPs in 940 familial colorectal tumor cases and 965 controls. In phase 2 we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3 we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls.
  • To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1 we genotyped 550 163 tagSNPs in 940 familial colorectal tumor cases and 965 controls. In phase 2 we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3 we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. (en)
  • Za účelem identifikace alel asociovaných s rizikem vzniku kolorektálního karcinomu (CRC), byla provedená celogenomová studie. V první fázi bylo analyzováno 550 163 SNPs u 940 pacientů s familiární formou CRC a u 965 kontrolních jedinců. V druhé fázi jsme analyzovali 42 708 vybraných SNPs u 2 873 CRC pacientů a 2 871 kontrol. Třetí fáze byla zaměřena už pouze na 11 vybraných SNPs prokazujících vysokou asociaci na hladině signifikance P < 10(-4) u 4 287 CRC pacientů a 3 743 kontrol. (cs)
Title
  • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
  • Celogenomová asociační studie analyzujíci lokusy na chromozomu 10p14 a 8q23.3. ve vztahu k náchylnosti na vznik kolorektálního karcinomu (cs)
  • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 (en)
skos:prefLabel
  • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
  • Celogenomová asociační studie analyzujíci lokusy na chromozomu 10p14 a 8q23.3. ve vztahu k náchylnosti na vznik kolorektálního karcinomu (cs)
  • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 (en)
skos:notation
  • RIV/68378041:_____/08:00306557!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany
  • 623;630
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA310/07/1430), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 354207
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/08:00306557
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Colorectal cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [79FC8F83DAAE]
http://linked.open...i/riv/nazevZdroje
  • Nature Genetics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 40
http://linked.open...iv/tvurceVysledku
  • Försti, A.
  • Hemminki, K.
  • Naccarati, Alessio
  • Vodička, Pavel
  • …
  • Buch, S.
  • Hampe, J.
  • Schafmayer, C.
  • Völzke, H.
  • Carracedo, A.
  • Carvajal-Carmona, L.
  • Castells, A.
  • Castellví-Bel, S.
  • Ho, J. W. C.
  • Lipton, L.
  • Morreau, H.
  • Ruiz-Ponte, C.
  • Tenesa, A.
  • Wijnen, J. T.
  • van Wezel, T.
  • Sullivan, K.
  • John, U.
  • Pharoah, P.
  • Gorman, M.
  • Aaltonen, L.
  • Domingo, E.
  • Walter, A.
  • Broderick, P.
  • Koessler, T.
  • Penegar, S.
  • Tomlinson, I. P. M.
  • Kerr, D.
  • Giles, G. G.
  • Martin, L.
  • Agúndez, J. A. G.
  • Barclay, E.
  • Barnetson, R. A.
  • Bishop, D. T.
  • Caldés, T.
  • Chandler, I.
  • Cheng, K. K.
  • Evans, D. G. R.
  • Farrington, S. M.
  • Fielding, S.
  • Gray, R.
  • Hopper, J. L.
  • Howarth, K.
  • Jäger, E.
  • Karhu, A.
  • Kemp, Z.
  • Ladero, J. M.
  • Lubbe, S.
  • Lucassen, A.
  • Luk, J.
  • Maher, E. R.
  • Niittymäki, I.
  • Peto, J.
  • Pittman, A. M.
  • Prendergast, J. G. D.
  • Qureshi, M.
  • Rowan, A.
  • Schreber, S.
  • Severi, G.
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