About: Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Micro-RNA (miRNAs) mají schopnost se vázat na 3´konce mRNA (UTRs) a modifikovat její translaci. Regulace pomocí miRNA může být ovlivněná polymorfismem v 3´UTR oblastech. Předpokládáme, že polymorfizmy v miRNA vážících se oblastech sehrávají roli při individuální vnímavosti na riziko vzniku rakoviny. V předkládané studii jsme analyzovali 3´UTR oblasti u 104 kandidátních genů pro kolorektální karcinom. (cs) Micro-RNAs (miRNAs) can bind to the 3' untranslated regions (UTRs) of messenger RNAs and interfere with their translation. Furthermore, miRNA regulation may be affected by polymorphisms on the 3' UTRs. We hypothesize that common polymorphisms within miRNA-target binding sites could play a role in the individual risk of cancer. In the present study, we selected and analysed the 3' UTRs of 104 genes candidate for colorectal cancer. Micro-RNAs (miRNAs) can bind to the 3' untranslated regions (UTRs) of messenger RNAs and interfere with their translation. Furthermore, miRNA regulation may be affected by polymorphisms on the 3' UTRs. We hypothesize that common polymorphisms within miRNA-target binding sites could play a role in the individual risk of cancer. In the present study, we selected and analysed the 3' UTRs of 104 genes candidate for colorectal cancer. (en)
Title	Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer Polymorfizmy micro-RNA vazebních oblastí ve vztahu k riziku vzniku kolorektálního karcinomu. (cs) Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer (en)
skos:prefLabel	Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer Polymorfizmy micro-RNA vazebních oblastí ve vztahu k riziku vzniku kolorektálního karcinomu. (cs) Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer (en)
skos:notation	RIV/68378041:_____/08:00306350!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany	579;584
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/05/2626), P(GA310/07/1430), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Vodičková, Ludmila Vodička, Pavel Naccarati, Alessio Pardini, Barbara
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	387440
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/08:00306350
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Colorectal cancer; Messenger RNA; Micro-RNA (en)
http://linked.open.../riv/klicoveSlovo	Colorectal cancer Messenger RNA Micro-RNA
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BC4CE9CFC1CF]
http://linked.open...i/riv/nazevZdroje	Carcinogenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic. Case-control study on colorectal carcinoma: genetic profiling of xenobiotic metabolising and DNA repair enzymes
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Canzian, F. Försti, A. Hemminki, K. Naccarati, Alessio Novotný, J. Pardini, Barbara Vodička, Pavel Vodičková, Ludmila Gemignani, F. Landi, D. Landi, S.
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0143-3334
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer

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