About: Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers

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About: Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Článek předkládá výsledky biomonitorovací studie sledující problematiku profesionální expozice karcinogénům. V studii se analyzuje individuální reparační kapacita oxidačních poškození DNA, která je součástí mechanizmu bázový excizní opravy, jako i individuální susceptibilitu ve vztahu k některým parametrům genotoxicity u lidí profesionálně exponovaných styrénu. (cs) The article is devoted to analysis of capacity to repair oxidative DNA damage in lymphocyte extracts of 24 lamination workers occupationally exposed to styrene and compared with 15 unexposed controls using the modified comet assay. Influence of parameters of external and internal styrene exposure, the extent of DNA damage (DNA strand breaks, N1-styrene-adenine DNA adducts), chromosomal damage (chromosomal aberrations), mutant frequencies at the HPRT and SNPs in DNA repair genes on individual DNA repair capacity was evaluated. The article is devoted to analysis of capacity to repair oxidative DNA damage in lymphocyte extracts of 24 lamination workers occupationally exposed to styrene and compared with 15 unexposed controls using the modified comet assay. Influence of parameters of external and internal styrene exposure, the extent of DNA damage (DNA strand breaks, N1-styrene-adenine DNA adducts), chromosomal damage (chromosomal aberrations), mutant frequencies at the HPRT and SNPs in DNA repair genes on individual DNA repair capacity was evaluated. (en)
Title	Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers Vztah mezi schopnosti opravy 8-oxoguaninu, biomarkeru genotoxicity a (cs) Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers (en)
skos:prefLabel	Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers Vztah mezi schopnosti opravy 8-oxoguaninu, biomarkeru genotoxicity a (cs) Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers (en)
skos:notation	RIV/68378041:_____/07:00093932!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany	101;111
http://linked.open...avai/riv/aktivita	P R Z
http://linked.open...avai/riv/aktivity	P(GA310/05/2626), P(NR8563), R, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Vodičková, Ludmila Vodička, Pavel Slyšková, Jana Tulupova, Elena Naccarati, Alessio
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	447196
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00093932
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Occupational exposure; Styrene; Oxidative damage (en)
http://linked.open.../riv/klicoveSlovo	Occupational exposure Styrene Oxidative damage
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9D27B95D3783]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Case-control study on colorectal carcinoma: genetic profiling of xenobiotic metabolising and DNA repair enzymes Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	634
http://linked.open...iv/tvurceVysledku	Naccarati, Alessio Vodička, Pavel Vodičková, Ludmila Souček, P. Slyšková, Jana Tulupová, Elena Kuricová, M. Susová, S. Dušinská, M.
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1383-5718
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotxicity and individual susceptibility in styrene-exposed workers

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