| Attributes | Values |
|---|
| rdf:type
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| Description
| - Plně vyrostlé oocyty (FGO) obsahují všechny transkripty, které jsou nezbytné pro aktivaci molekulárních procesů klíčových pro vývojový přechod od oocytu k embryu (OET). S cílem objasnit toto kritické období vývoje, byla v této studii provedena analýza 19 000 exprimovaných sekvencí cDNA knihovny připravené z Mus musculus FGO. Je popsána exprese 5400 genů. Srovnání transkriptomů FGO naznačilo procesy důležité pro oogenezu a identifikovalo nové motivy zodpovědné za stabilitu maternalní mRNA. Výsledky odhalují konzervované molekulární cesty zodpovědné za přechod od oocytu k iniciaci embryonálního vývoje a ilustrují, jak geny během evoluce získávají a ztrácí reprodukční funkce. (cs)
- Fully grown oocytes (FGOs) contain all the necessary transcripts to activate molecular pathways underlying the oocyte-to-embryo transition (OET). To elucidate this critical period of development, an extensive survey of the FGO transcriptome was performed by analyzing 19,000 expressed sequence tags of the Mus musculus FGO cDNA library. Expression of 5400 genes and transposable elements is reported. Comparison of the FGO and two-cell embryo transcriptomes demarcated the processes important for oogenesis from those involved in OET and identified novel motifs in maternal mRNAs associated with transcript stability. The results implicate conserved pathways underlying transition from oogenesis to initiation of development and illustrate how genes acquire and lose reproductive functions during evolution, a potential mechanism for reproductive isolation.
- Fully grown oocytes (FGOs) contain all the necessary transcripts to activate molecular pathways underlying the oocyte-to-embryo transition (OET). To elucidate this critical period of development, an extensive survey of the FGO transcriptome was performed by analyzing 19,000 expressed sequence tags of the Mus musculus FGO cDNA library. Expression of 5400 genes and transposable elements is reported. Comparison of the FGO and two-cell embryo transcriptomes demarcated the processes important for oogenesis from those involved in OET and identified novel motifs in maternal mRNAs associated with transcript stability. The results implicate conserved pathways underlying transition from oogenesis to initiation of development and illustrate how genes acquire and lose reproductive functions during evolution, a potential mechanism for reproductive isolation. (en)
|
| Title
| - Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo
- Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo (en)
- %22Rozbití vejce: molekulární dynamika a evoluční aspekty přechodu mezi plně vyrostlým oocytem a embryem%22. (cs)
|
| skos:prefLabel
| - Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo
- Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo (en)
- %22Rozbití vejce: molekulární dynamika a evoluční aspekty přechodu mezi plně vyrostlým oocytem a embryem%22. (cs)
|
| skos:notation
| - RIV/68378041:_____/06:00043890!RIV07-AV0-68378041
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378041:_____/06:00043890
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Eukaryotic initiation factor 4E; mRNA stability; Multigene family (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hampl, Aleš
- Singh, P.
- Eppig, J. J.
- Solter, D.
- Brockman, J. M.
- Evsikov, A. V.
- Graber, J. H.
- Holbrook, A. E.
- Knowles, B. B.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| is http://linked.open...avai/riv/vysledek
of | |
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