About: Secreted proteins as a fundamental source for biomarker discovery

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We discuss the proteins secreted by three progenitor cell types (smooth muscle, endothelial and cardiac progenitor cells) and two adult cell types (neonatal rat ventrical myocytes and smooth muscle cells) which can be relevant to cardiovascular research and which have been recently published in the literature. We found, at least for secretome studies included in this review, that secretomes of progenitor and adult cells overlap by 48% but the secretomes are very distinct among progenitor cell themselves as well as between adult cells. As expected, many proteins have been identified as biomarkers in cancer but 18 proteins (out of 62) have been tested as biomarkers in cardiovascular diseases as well. We discuss the proteins secreted by three progenitor cell types (smooth muscle, endothelial and cardiac progenitor cells) and two adult cell types (neonatal rat ventrical myocytes and smooth muscle cells) which can be relevant to cardiovascular research and which have been recently published in the literature. We found, at least for secretome studies included in this review, that secretomes of progenitor and adult cells overlap by 48% but the secretomes are very distinct among progenitor cell themselves as well as between adult cells. As expected, many proteins have been identified as biomarkers in cancer but 18 proteins (out of 62) have been tested as biomarkers in cardiovascular diseases as well. (en)
Title	Secreted proteins as a fundamental source for biomarker discovery Secreted proteins as a fundamental source for biomarker discovery (en)
skos:prefLabel	Secreted proteins as a fundamental source for biomarker discovery Secreted proteins as a fundamental source for biomarker discovery (en)
skos:notation	RIV/68081715:_____/12:00376119!RIV13-AV0-68081715
http://linked.open...avai/predkladatel	Ústav analytické chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z40310501)
http://linked.open...iv/cisloPeriodika	4-5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Šťastná, Miroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav analytické chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	167159
http://linked.open...ai/riv/idVysledku	RIV/68081715:_____/12:00376119
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	conditioned media; secreted proteins; proteomics; biomarker discovery (en)
http://linked.open.../riv/klicoveSlovo	conditioned media biomarker discovery secreted proteins proteomics
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[22C73E5D9434]
http://linked.open...i/riv/nazevZdroje	Proteomics
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Van Eyk, J. E. Šťastná, Miroslava
http://linked.open...ain/vavai/riv/wos	000302151800018
http://linked.open...n/vavai/riv/zamer	Moderní analytické techniky pro bioanalýzu, ekologii a nanotechnologie
issn	1615-9853
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/pmic.201100346
is http://linked.open...avai/riv/vysledek of	Secreted proteins as a fundamental source for biomarker discovery

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