About: Nuclear Structures Surrounding Internal Lamin Invaginations

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A- and C-type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C-type lamins into the nuclear interior represent channels for the transport of regulatory molecules to and from nuclear and nucleolar regions. Using fluorescent protein technology and immunofluorescence, we show that A-type lamin channels interact with several nuclear components, including fibrillarin- and UBF-positive regions of nucleoli, foci of heterochromatin protein 1 , polycomb group bodies, and genomic regions associated with DNA repair. Similar associations were observed between A/C-type lamin channels and nuclear pores, lamin-associated protein LAP2, and promyelocytic leukemia nuclear bodies. Interestingly, regions with high levels of A/C-type lamins had low levels of B-type lamins, and vice versa. A- and C-type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C-type lamins into the nuclear interior represent channels for the transport of regulatory molecules to and from nuclear and nucleolar regions. Using fluorescent protein technology and immunofluorescence, we show that A-type lamin channels interact with several nuclear components, including fibrillarin- and UBF-positive regions of nucleoli, foci of heterochromatin protein 1 , polycomb group bodies, and genomic regions associated with DNA repair. Similar associations were observed between A/C-type lamin channels and nuclear pores, lamin-associated protein LAP2, and promyelocytic leukemia nuclear bodies. Interestingly, regions with high levels of A/C-type lamins had low levels of B-type lamins, and vice versa. (en)
Title	Nuclear Structures Surrounding Internal Lamin Invaginations Nuclear Structures Surrounding Internal Lamin Invaginations (en)
skos:prefLabel	Nuclear Structures Surrounding Internal Lamin Invaginations Nuclear Structures Surrounding Internal Lamin Invaginations (en)
skos:notation	RIV/68081707:_____/14:00427969!RIV15-AV0-68081707
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(LD11020)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Legartová, Soňa Stixová, Lenka Bártová, Eva Kozubek, Stanislav Sehnalová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	33232
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/14:00427969
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	LAMINS; NUCLEAR PORES; CHROMATIN (en)
http://linked.open.../riv/klicoveSlovo	CHROMATIN LAMINS NUCLEAR PORES
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5DEFD21DA1E9]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Epigenetics normal and tumor cells.
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	115
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Legartová, Soňa Stixová, Lenka Sehnalová, Petra Laur, O.
http://linked.open...ain/vavai/riv/wos	000330906300007
issn	0730-2312
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jcb.24681

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