About: Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effects of major DNA intrastrand cross-links of antitumor dinuclear Pt-II complexes [{trans-PtCl(NH3)(2)}(2)-mu-{trans-(H2N(CH2)(6)NH2(CH2)(2)NH2(CH2)(6) NH2)}](4+) (1) and [{PtCl(DACH)}(2)-mu-{H2N(CH2)(6)NH2 (CH2)(2)NH2(CH2)(6)NH2)}](4+) (2) (DACH is 1,2-diaminocyclohexane) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes containing the single 1,2, 1,3, or 1,5 intrastrand cross-links at guanine residues in the central TGGT, TGTGT, or TGTTTGT sequences, respectively, were prepared and analyzed by differential scanning calorimetry. The unfolding of the platinated duplexes was accompanied by unfavorable free energy terms. The effects of major DNA intrastrand cross-links of antitumor dinuclear Pt-II complexes [{trans-PtCl(NH3)(2)}(2)-mu-{trans-(H2N(CH2)(6)NH2(CH2)(2)NH2(CH2)(6) NH2)}](4+) (1) and [{PtCl(DACH)}(2)-mu-{H2N(CH2)(6)NH2 (CH2)(2)NH2(CH2)(6)NH2)}](4+) (2) (DACH is 1,2-diaminocyclohexane) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes containing the single 1,2, 1,3, or 1,5 intrastrand cross-links at guanine residues in the central TGGT, TGTGT, or TGTTTGT sequences, respectively, were prepared and analyzed by differential scanning calorimetry. The unfolding of the platinated duplexes was accompanied by unfavorable free energy terms. (en)
Title	Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes (en)
skos:prefLabel	Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes (en)
skos:notation	RIV/68081707:_____/12:00389601!RIV13-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP301/10/0598), P(GD301/09/H004), P(ME10066)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Florián, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	174303
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00389601
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NUCLEOTIDE EXCISION-REPAIR; PLATINUM ANTICANCER DRUGS; GROUP DOMAIN PROTEINS (en)
http://linked.open.../riv/klicoveSlovo	GROUP DOMAIN PROTEINS NUCLEOTIDE EXCISION-REPAIR PLATINUM ANTICANCER DRUGS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7C7F3533D335]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer Transition metal-based anticancer compounds. From mechanistic studies to innovatory cancer chemotherapy
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Farell, N. P. Florian, Jakub
http://linked.open...ain/vavai/riv/wos	000301185800003
issn	0949-8257
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00775-011-0841-4
is http://linked.open...avai/riv/vysledek of	Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes

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