About: Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues

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About: Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The cellular and molecular pharmacology of the new class of anticancer drugs, in which CDK inhibitor bohemine and its analogues are coordinated to Pt(II) to form cisplatin derivatives, was investigated. The results revealed the unique anticancer profile of a cisplatin-derived platinum(II) dichlorido complex involving N(7)-coordinated bohemine (C1). The results also showed that the distinct differences in cell killing observed for C1 and cisplatin might be associated with processes at the DNA level. It was concluded that C1 remains a promising prototype of compounds for the generation of novel drug candidates with cytotoxicity profiles different from those of platinum drugs currently in use. The cellular and molecular pharmacology of the new class of anticancer drugs, in which CDK inhibitor bohemine and its analogues are coordinated to Pt(II) to form cisplatin derivatives, was investigated. The results revealed the unique anticancer profile of a cisplatin-derived platinum(II) dichlorido complex involving N(7)-coordinated bohemine (C1). The results also showed that the distinct differences in cell killing observed for C1 and cisplatin might be associated with processes at the DNA level. It was concluded that C1 remains a promising prototype of compounds for the generation of novel drug candidates with cytotoxicity profiles different from those of platinum drugs currently in use. (en)
Title	Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues (en)
skos:prefLabel	Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues (en)
skos:notation	RIV/68081707:_____/12:00376804!RIV13-GA0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP301/10/0598), P(GD301/09/H004)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kostrhunová, Hana Brabec, Viktor Nováková, Olga Lišková, Barbora Zerzánková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	126234
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00376804
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin; DNA; bohemine (en)
http://linked.open.../riv/klicoveSlovo	bohemine DNA cisplatin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[37535513D508]
http://linked.open...i/riv/nazevZdroje	Chemical Research in Toxicology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kostrhunová, Hana Zerzánková, Lenka Lišková, Barbora Nováková, Olga Trávníček, Z.
http://linked.open...ain/vavai/riv/wos	000300470300027
issn	0893-228X
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/tx200525n
is http://linked.open...avai/riv/vysledek of	Cellular response to antitumor cis-dichlorido platinum(II) complexes of CDK inhibitor bohemine and its analogues

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