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  • The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (acrivastine, ketotifen, and loratadine) on the respiratory burst of phagocytes. Reactive oxygen species generation in neutrophils isolated from rat blood was measured using luminol-enhanced chemiluminescence. Changes in nitrite formation and iNOS protein expression by RAW 264.7 macrophages were analysed using Griess reaction and Western blotting. The antioxidative properties of drugs in cell-free systems were detected spectrophotometrically, luminometrically, fluorimetrically, and amperometrically. The majority of the H(1)-antihistamines tested (bromadryl, brompheniramine, chlorcyclizine, chlorpheniramine, clemastine, dithiaden, and ketotifen) exhibited a significant inhibitory effect on the chemiluminescence activity of phagocytes.
  • The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (acrivastine, ketotifen, and loratadine) on the respiratory burst of phagocytes. Reactive oxygen species generation in neutrophils isolated from rat blood was measured using luminol-enhanced chemiluminescence. Changes in nitrite formation and iNOS protein expression by RAW 264.7 macrophages were analysed using Griess reaction and Western blotting. The antioxidative properties of drugs in cell-free systems were detected spectrophotometrically, luminometrically, fluorimetrically, and amperometrically. The majority of the H(1)-antihistamines tested (bromadryl, brompheniramine, chlorcyclizine, chlorpheniramine, clemastine, dithiaden, and ketotifen) exhibited a significant inhibitory effect on the chemiluminescence activity of phagocytes. (en)
Title
  • Modulation of metabolic activity of phagocytes by antihistamines.
  • Modulation of metabolic activity of phagocytes by antihistamines. (en)
skos:prefLabel
  • Modulation of metabolic activity of phagocytes by antihistamines.
  • Modulation of metabolic activity of phagocytes by antihistamines. (en)
skos:notation
  • RIV/68081707:_____/11:00441596!RIV15-AV0-68081707
http://linked.open...avai/riv/aktivita
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  • I
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  • 1
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  • 213434
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  • RIV/68081707:_____/11:00441596
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  • antihistamines; nitric oxide; oxidative burst (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [6D7A6F83E826]
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  • Interdisciplinary Toxicology
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  • 4
http://linked.open...iv/tvurceVysledku
  • Kubala, Lukáš
  • Lojek, Antonín
  • Moravcová, Jana
  • Pekarová, Michaela
  • Ambrožová, Gabriela
  • Vašíček, Ondřej
  • Drábiková, K.
  • Jančinová, V.
  • Číž, Milan
  • Perečko, Tomáš
issn
  • 1337-6853
number of pages
http://bibframe.org/vocab/doi
  • 10.2478/v10102-011-0004-z
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