About: Non-telomeric activities of telomerase

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent results suggest that telomerase is involved in many more cellular processes than merely telomere elongation. These include telomere-independent anti-apoptotic, cytoprotective and pro-proliferative effects of telomerase or protection of mitochondrial DNA against oxidative stress. Telomerase also participates in DNA repair and its essential subunits, hTR and hTERT, are able to modulate independently the cell's response to DNA damage. Recent high throughput analyses of gene expression showed that hTERT expression modulates expression of about 300 genes, including genes involved in the regulation of cell cycle progression, proliferation and differentiation. Besides the well-known telomerase catalytic activity of RNA-dependent DNA polymerase, its RNA-dependent RNA polymerase activity was recently described in association with the RNA subunit of mitochondrial RNA processing endoribonuclease, thus suggesting involvement of telomerase in RNA interference processes. Recent results suggest that telomerase is involved in many more cellular processes than merely telomere elongation. These include telomere-independent anti-apoptotic, cytoprotective and pro-proliferative effects of telomerase or protection of mitochondrial DNA against oxidative stress. Telomerase also participates in DNA repair and its essential subunits, hTR and hTERT, are able to modulate independently the cell's response to DNA damage. Recent high throughput analyses of gene expression showed that hTERT expression modulates expression of about 300 genes, including genes involved in the regulation of cell cycle progression, proliferation and differentiation. Besides the well-known telomerase catalytic activity of RNA-dependent DNA polymerase, its RNA-dependent RNA polymerase activity was recently described in association with the RNA subunit of mitochondrial RNA processing endoribonuclease, thus suggesting involvement of telomerase in RNA interference processes. (en)
Title	Non-telomeric activities of telomerase Non-telomeric activities of telomerase (en)
skos:prefLabel	Non-telomeric activities of telomerase Non-telomeric activities of telomerase (en)
skos:notation	RIV/68081707:_____/11:00440856!RIV15-GA0-68081707
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA204/08/1530), P(IAA500040801), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Fajkus, Jiří Sýkorová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	216282
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00440856
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GROWTH-FACTOR RECEPTOR; CENTRAL-NERVOUS-SYSTEM; COMPLEX-I DEFICIENCY (en)
http://linked.open.../riv/klicoveSlovo	CENTRAL-NERVOUS-SYSTEM COMPLEX-I DEFICIENCY GROWTH-FACTOR RECEPTOR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C166F1856FE7]
http://linked.open...i/riv/nazevZdroje	Molecular BioSystems
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Understanding of HMGB1 protein involvement in maintaining genome stability Telomeres and telomerase: transition from molecular to structural biology approach.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Sýkorová, Eva Fajkus, Jiří Majerská, J.
http://linked.open...ain/vavai/riv/wos	000288329300005
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1742-206X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c0mb00268b

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