| Attributes | Values |
|---|
| rdf:type
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| Description
| - V předkládané studii byly pomocí vysokokapacitních cDNA čipu obsahujících 19,000 sekvencí, provedeny studie expresních profilů promyelotických leukemických buněk HL-60 diferencujících do monocytů (MD) a granulocytů (GD). Jako diferenciační činidlo pro monocytární diferenciaci bylo použito TPA (12-O-tetradecanoylphorbol-D-acetate) a pro granulocytární proces DMSO. Studiem expresních profilů bylo zjištěno že v průběhu MD signifikantně měnilo expresi 4625 genů a v průběhu GD 4760 genů. Geny obou diferenciací byly rozděleny do podle typu kinetiky s jakou se účastní diferenciace do tzv. R-skupin. Bylo zjištěno, že geny z jednotlivých R-skupin nejsou nenáhodně rozprostřeny na chromosomových teritorií, ale formují na chromosomech klastry. Skupiny genu s podobnou kinetikou regulace tedy můžeme najít na chromosomech blízko sebe. (cs)
- In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule.
- In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule. (en)
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| Title
| - Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
- Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells (en)
- Klastrování genů s podobným regulačním mechanismem během monocytární a garanulocytární diferenciace buněk HL-60 (cs)
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| skos:prefLabel
| - Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
- Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells (en)
- Klastrování genů s podobným regulačním mechanismem během monocytární a garanulocytární diferenciace buněk HL-60 (cs)
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| skos:notation
| - RIV/68081707:_____/04:00108489!RIV/2005/AV0/A17005/N
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1A8241), P(GP301/04/P136), Z(AV0Z5004920), Z(MSM 143300002)
|
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/04:00108489
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - gene expression; leukaemia cell line HL60; cDNA (en)
|
| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
| |
| http://linked.open...i/riv/nazevZdroje
| - Biophysics of the Genome: Proceedings of the Workshop Held at Brno
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Bártová, Eva
- Kozubek, Stanislav
- Pavlík, T.
- Kozubek, M.
- Svoboda, Z.
- Koutná, I.
- Krontorád, P.
- Faltýsková, E.
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| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
| |
| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Masarykova univerzita v Brně
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| https://schema.org/isbn
| |
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