About: Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.

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About: Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nordihydroguaiaretic acid (NDGA) and esculetin, both inhibitors of lipoxygenase, were found to suppress proliferation of murine G:5:113 fibrosarcoma cells in vitro. However, they had no curative effects in experiments in vivo when repeatedly administered to mice bearing tumours growing from subcutaneously transplanted G:5:113 cells. The results demonstrate the necessity of experiments in vivo for evaluating contingent anticancer effects of newly tested substances. Nordihydroguaiaretic acid (NDGA) and esculetin, both inhibitors of lipoxygenase, were found to suppress proliferation of murine G:5:113 fibrosarcoma cells in vitro. However, they had no curative effects in experiments in vivo when repeatedly administered to mice bearing tumours growing from subcutaneously transplanted G:5:113 cells. The results demonstrate the necessity of experiments in vivo for evaluating contingent anticancer effects of newly tested substances. (en)
Title	Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo. Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo. (en)
skos:prefLabel	Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo. Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo. (en)
skos:notation	RIV/68081707:_____/03:17033012!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	102;109
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IBS5004009), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hoferová, Zuzana Hofer, Michal Hofmanová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	613660
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033012
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fibrosarcoma; lipoxygenase inhibitors (en)
http://linked.open.../riv/klicoveSlovo	lipoxygenase inhibitors fibrosarcoma
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[45142443ABDB]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Untraditional therapeutic approaches in oncology
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Hofer, Michal Hoferová, Zuzana Kozubík, Alois Fedoročko, P. Eliášová, V.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0028-2685
number of pages	8 (xsd:int)

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