About: Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action.

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About: Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aims of the present study were to determine potencies of a series of environmentally relevant PCB congeners to inhibit GJIC invitro, and to screen for intrcellular signaling pathways potentially involved in GJIC downregulation by PCBs. It was found that a number of nonplanar PCB congeners are efficient inhibitors of GJIC in vitro, and that a model compound, PCB153, does not act via activation of PKC or ERK1/2, which is contrast with the effects of protoypical inhibitors of GJIC, such as TPA or EGF. The aims of the present study were to determine potencies of a series of environmentally relevant PCB congeners to inhibit GJIC invitro, and to screen for intrcellular signaling pathways potentially involved in GJIC downregulation by PCBs. It was found that a number of nonplanar PCB congeners are efficient inhibitors of GJIC in vitro, and that a model compound, PCB153, does not act via activation of PKC or ERK1/2, which is contrast with the effects of protoypical inhibitors of GJIC, such as TPA or EGF. (en)
Title	Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. (en)
skos:prefLabel	Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. (en)
skos:notation	RIV/68081707:_____/02:17023118!RIV/2003/GA0/A17003/N
http://linked.open.../vavai/riv/strany	155;158
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/00/D101), P(QC0194), Z(AV0Z5004920)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Vondráček, Jan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	649161
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/02:17023118
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PCBs; GJIC inhibition; tumor promotion (en)
http://linked.open.../riv/klicoveSlovo	tumor promotion PCBs GJIC inhibition
http://linked.open...ontrolniKodProRIV	[C6124EF05AC6]
http://linked.open...v/mistoKonaniAkce	Brno [CZ]
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./ Book of Abstracts.
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Biochemical markers of dioxin-like toxicity and further specific effects of xenobiotics In vitro methods for detection and studies of epigenetic toxicity of xenobiotics
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Machala, M. Vondráček, Jan Bláha, L. Upham, B. L.
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2002-10-14 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Masarykova univerzita

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