About: Sequence Specificity, Corformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes.

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About: Sequence Specificity, Corformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dinuclear platinum complexes form on DNA several types of long-range interstrand cross-links in which each platinum moiety behaves as isolated monofunctional adduct. The conformational distortions caused in duplex DNA by formation of these adduct differ distinctly of those caused by interstrand cross-links of cisplatin. The main differences are flexible nondirectional bend, and a much lower ability of HMG1 protein to recognize these adducts. Dinuclear platinum complexes form on DNA several types of long-range interstrand cross-links in which each platinum moiety behaves as isolated monofunctional adduct. The conformational distortions caused in duplex DNA by formation of these adduct differ distinctly of those caused by interstrand cross-links of cisplatin. The main differences are flexible nondirectional bend, and a much lower ability of HMG1 protein to recognize these adducts. (en)
Title	Sequence Specificity, Corformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes. Sequence Specificity, Corformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes. (en)
skos:prefLabel	Sequence Specificity, Corformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes. Sequence Specificity, Corformation, and Recognition by HMG1 Protein of Major DNA Interstrand Cross-links of Antitumor Dinuclear Platinum Complexes. (en)
skos:notation	RIV/68081707:_____/00:17000115!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany	15789;15798
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/99/0695), P(GA307/97/P029), P(IAA5004702), P(ME 152), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	726246
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/00:17000115
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[86354291B77A]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Affection of DNA conformation by metal-based anticancer drugs. Relations to the development of new cytostatics Molecular mechanism of antitumor activity of bisplatinum complexes Effects of geometric isomerism in antitumor dinuclear platinum complexes on binding properties and conformational alterations in DNA http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20152
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	275
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Farrell, N.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0021-9258
number of pages	10 (xsd:int)

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