About: Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.     Goto   Sponge   NotDistinct   Permalink

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Description
  • The complexes trans-/PtCl2(NH3)chinoline/ and trans-/PtCl2(NH3)thiazole/ form on DNA interstrand cross-links which are formally indentical to those formed clinically efficient cisplatin. These interstrand cross-links were studied by means of Maxam - Gilbert reactions. The results show how a simple modification of the ligand of clinically inefficient transplatin can lead to dramatic changes in antitumor efficiency.
  • The complexes trans-/PtCl2(NH3)chinoline/ and trans-/PtCl2(NH3)thiazole/ form on DNA interstrand cross-links which are formally indentical to those formed clinically efficient cisplatin. These interstrand cross-links were studied by means of Maxam - Gilbert reactions. The results show how a simple modification of the ligand of clinically inefficient transplatin can lead to dramatic changes in antitumor efficiency. (en)
Title
  • Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.
  • Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups. (en)
skos:prefLabel
  • Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.
  • Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups. (en)
skos:notation
  • RIV/68081707:_____/00:17000114!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany
  • 364;368
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/98/P231), P(GA305/99/0695), P(GA307/97/P029), P(IAA5004702), P(ME 152), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika
  • N/A
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 727837
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/00:17000114
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • N/A (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [5E56CB68C204]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 5
http://linked.open...iv/tvurceVysledku
  • Brabec, Viktor
  • Kašpárková, Jana
  • Neplechová, Kamila
  • Farrell, N.
http://linked.open...n/vavai/riv/zamer
issn
  • 0949-8257
number of pages
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