About: Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Gametogenesis and fertilization are the key events in sexual reproduction. In the female, meiosis results in a large oocyte that is competent for fertilization and fundamental for the success of early embryonic development. Progression through meiosis is monitored by fine regulatory mechanisms. In this review, we focus on one of the most well-known regulatory elements, the E3 ligase APC/C, which mediates proteolytic degradation of a number of important substrates via the ubiquitin proteasome pathway (UPP). The UPP also indirectly regulates protein synthesis by affecting proteins involved in RNA metabolism, a process that is paramount for the transcriptionally silent oocyte. During the past few years, more evidence has accumulated to suggest that the UPP has an important role in zona pellucida penetration and gamete fusion in mammals. This review focuses on the function of the UPP in regulating oocyte meiotic maturation in mammals, with special attention to its role in chromosome segregation and polar body extrusion, its role in the acquisition of meiotic/developmental competence and recent advances in our understanding of the UPP role in fertilization. Gametogenesis and fertilization are the key events in sexual reproduction. In the female, meiosis results in a large oocyte that is competent for fertilization and fundamental for the success of early embryonic development. Progression through meiosis is monitored by fine regulatory mechanisms. In this review, we focus on one of the most well-known regulatory elements, the E3 ligase APC/C, which mediates proteolytic degradation of a number of important substrates via the ubiquitin proteasome pathway (UPP). The UPP also indirectly regulates protein synthesis by affecting proteins involved in RNA metabolism, a process that is paramount for the transcriptionally silent oocyte. During the past few years, more evidence has accumulated to suggest that the UPP has an important role in zona pellucida penetration and gamete fusion in mammals. This review focuses on the function of the UPP in regulating oocyte meiotic maturation in mammals, with special attention to its role in chromosome segregation and polar body extrusion, its role in the acquisition of meiotic/developmental competence and recent advances in our understanding of the UPP role in fertilization. (en)
Title	Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals (en)
skos:prefLabel	Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals (en)
skos:notation	RIV/67985904:_____/11:00377696!RIV13-GA0-67985904
http://linked.open...avai/predkladatel	Ústav živočišné fyziologie a genetiky AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP502/10/0944), P(GD204/09/H084), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kubelka, Michal Karabínová, Pavla Šušor, Andrej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	224795
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/11:00377696
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Oocyte; Proteasome; Meiosis (en)
http://linked.open.../riv/klicoveSlovo	Oocyte Meiosis Proteasome
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F3370C1EE672]
http://linked.open...i/riv/nazevZdroje	Cell and Tissue Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular biology of a differentiating cell Maternal ageing effect on activities of major protein kinases regulating mammalian meiosis.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	346
http://linked.open...iv/tvurceVysledku	Kubelka, Michal Karabínová, Pavla Šušor, Andrej
http://linked.open...ain/vavai/riv/wos	000297123200001
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0302-766X
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00441-011-1235-1
is http://linked.open...avai/riv/vysledek of	Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals

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