About: Expression and characterization of c-Myb in prenatal odontogenesis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. (en)
Title	Expression and characterization of c-Myb in prenatal odontogenesis Expression and characterization of c-Myb in prenatal odontogenesis (en)
skos:prefLabel	Expression and characterization of c-Myb in prenatal odontogenesis Expression and characterization of c-Myb in prenatal odontogenesis (en)
skos:notation	RIV/67985904:_____/11:00368272!RIV12-AV0-67985904
http://linked.open...avai/predkladatel	Ústav živočišné fyziologie a genetiky AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/11/1418), P(GC524/08/J032), P(GP304/08/P289), P(KJB500450802), Z(AV0Z50450515), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Buchtová, Marcela Janečková, Eva Matalová, Eva Balková, Simona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	199014
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/11:00368272
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	morphogenesis; mouse; Myb (en)
http://linked.open.../riv/klicoveSlovo	Myb morphogenesis mouse
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[2F0F9D72E12F]
http://linked.open...i/riv/nazevZdroje	Development Growth & Differentiation
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Differentiation of human embryonic stem cells into odontogenic lineages Interactions of tooth, periodontium, and interdental bone development Mechanisms of cell death in the primary enamel knot Gene profiling of tooth initiation using microarray technology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Buchtová, Marcela Tucker, A. S. Balková, Simona Bender, T. P. Janečková, Eva Lungová, V. Matalová, Eva Šmarda, J.
http://linked.open...ain/vavai/riv/wos	000293902200004
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture Molecular basis of cell and tissue regulations
issn	0012-1592
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1440-169X.2011.01287.x
is http://linked.open...avai/riv/vysledek of	Expression and characterization of c-Myb in prenatal odontogenesis Expression and characterization of c-Myb in prenatal odontogenesis

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