About: Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice.

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About: Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bovine seminal ribonuclease(BS-RNase) is an antitumoral active enzyme exhibiting specific antitumoral action against a number of different cancer cell lines.However, its systemic use is limited by its pharmacokinetic properties and antigenicity.Therefore, it was conjugated to polyethylene glycol(PEG) chains to overcome these problems. In order to Investigate the antitumoral efficacy of BS-RNase-PEG 'In vivo', preliminary experiments on the effect of the conjugate on neuroblastoma growth in mice were performed in a UKF-NB-3 xenotransplantate model, demonstrating a drastically increased antitumoral activity of the conjugate compared to the free enzyme. Bovine seminal ribonuclease(BS-RNase) is an antitumoral active enzyme exhibiting specific antitumoral action against a number of different cancer cell lines.However, its systemic use is limited by its pharmacokinetic properties and antigenicity.Therefore, it was conjugated to polyethylene glycol(PEG) chains to overcome these problems. In order to Investigate the antitumoral efficacy of BS-RNase-PEG 'In vivo', preliminary experiments on the effect of the conjugate on neuroblastoma growth in mice were performed in a UKF-NB-3 xenotransplantate model, demonstrating a drastically increased antitumoral activity of the conjugate compared to the free enzyme. (en)
Title	Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice. Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice. (en)
skos:prefLabel	Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice. Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice. (en)
skos:notation	RIV/67985904:_____/02:21023018!RIV/2003/AV0/A21003/N
http://linked.open.../vavai/riv/strany	149;154
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/01/0114), P(KSK5052113), Z(AV0Z5045916)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Matoušek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	641843
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/02:21023018
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aspermatogenicity; BS-RNase; neuroblastoma (en)
http://linked.open.../riv/klicoveSlovo	neuroblastoma BS-RNase aspermatogenicity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[78B23902DB77]
http://linked.open...i/riv/nazevZdroje	Anti-Cancer Drugs
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Antitumor effects of bovine seminal ribonuclease on animal and human melanoblastoma, neuroblastoma, meduloblastoma and glioblastoma Structure, expression and interaction of the genome
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Matoušek, Josef Poucková, P. Langer, K. Cinatl, J. Kreuter, J. Cinátl, J. Michaelis, M.
http://linked.open...n/vavai/riv/zamer	Základní výzkum genetických struktur, fyziologických funkcí a vývojové biologie obratlovců se zaměřením na biomedicínsky, hospodářsky i jinak významné druhy
issn	0959-4973
number of pages	5 (xsd:int)

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