About: The strength of integrin binding between neutrophils and endothelial cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The strength of integrin binding between neutrophils and endothelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The firm adhesion of activated polymorphonuclear neutrophils to endothelial cells in blood vessels is achieved through binding of the integrin intercellular adhesion molecule. To contribute to the better understanding of this adhesion step, our investigation is aimed at the relationship between integrin expression and the strength of neutrophil binding to endothelial cells. Flow cytometry and 3D scanning microscopy are used to study integrin expression and distribution, respectively. It is found that CD11b/CD18 integrin expression is localized in clusters distributed irregularly over the neutrophil surface. After cell activation, the cluster distribution polarizes, increasing the local CD11b/CD18 density concurrently with nearly doubled integrin expression. The neutrophil adhesion efficiency is measured in a flow chamber coated successively by various substrates, including endothelial cells in an activated state. Analysis of the flow dependence of the number of attached cells reveals the prevailing number of neutrophils with stronger binding to the endothelium when both cells are in the activated state in comparison with non-activated cells. The firm adhesion of activated polymorphonuclear neutrophils to endothelial cells in blood vessels is achieved through binding of the integrin intercellular adhesion molecule. To contribute to the better understanding of this adhesion step, our investigation is aimed at the relationship between integrin expression and the strength of neutrophil binding to endothelial cells. Flow cytometry and 3D scanning microscopy are used to study integrin expression and distribution, respectively. It is found that CD11b/CD18 integrin expression is localized in clusters distributed irregularly over the neutrophil surface. After cell activation, the cluster distribution polarizes, increasing the local CD11b/CD18 density concurrently with nearly doubled integrin expression. The neutrophil adhesion efficiency is measured in a flow chamber coated successively by various substrates, including endothelial cells in an activated state. Analysis of the flow dependence of the number of attached cells reveals the prevailing number of neutrophils with stronger binding to the endothelium when both cells are in the activated state in comparison with non-activated cells. (en)
Title	The strength of integrin binding between neutrophils and endothelial cells The strength of integrin binding between neutrophils and endothelial cells (en)
skos:prefLabel	The strength of integrin binding between neutrophils and endothelial cells The strength of integrin binding between neutrophils and endothelial cells (en)
skos:notation	RIV/67985874:_____/03:00375893!RIV13-AV0-67985874
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/01/1605), Z(AV0Z2060917)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Říha, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav pro hydrodynamiku AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	629099
http://linked.open...ai/riv/idVysledku	RIV/67985874:_____/03:00375893
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endothelium; integrins; neutrophil adhesion; scanning microscopy (en)
http://linked.open.../riv/klicoveSlovo	endothelium scanning microscopy integrins neutrophil adhesion
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[4D3AE63060D5]
http://linked.open...i/riv/nazevZdroje	European Biophysics Journal With Biophysics Letters
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The effect of revealed receptor clusters on the regulation of adhesiveness and transmigration of white blood cells
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Říha, Pavel Wang, X. Stoltz, J. F. Muller, S. Dumas, D. Labrador, V.
http://linked.open...ain/vavai/riv/wos	000187309600004
http://linked.open...n/vavai/riv/zamer	Mechanics and transport phenomena in liquid systems and hydrosphere
issn	0175-7571
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00249-003-0329-4

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 91 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software