About: Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators—pralidoxime, obidoxime and HI-6—which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime. Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators—pralidoxime, obidoxime and HI-6—which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime. (en)
Title	Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon (en)
skos:prefLabel	Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon (en)
skos:notation	RIV/67985858:_____/09:00333208!RIV11-AV0-67985858
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(IAA603020901), S, Z(AV0Z40720504), Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Církva, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav chemických procesů AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	330033
http://linked.open...ai/riv/idVysledku	RIV/67985858:_____/09:00333208
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; reactivator; oxime (en)
http://linked.open.../riv/klicoveSlovo	acetylcholinesterase oxime reactivator
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[BEB795DB603D]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Actinomycete and fungi contribution to the decomposition of plant litter in the ecosystems contaminated with heavy metals.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Církva, Vladimír Pohanka, M. Musilová, L. Jun, D. Kuča, K. Musílek, K. Hrabinová, M. Paar, M. Paleček, J. Zdarová Karasová, J.
http://linked.open...ain/vavai/riv/wos	000273043200009
http://linked.open...n/vavai/riv/zamer	Investigation of multiphase reacting systems for the design of processes important in synthesis and preparation of novel materials, in energy production and in environmental protection Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	1420-3049
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

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