About: In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei     Goto   Sponge   NotDistinct   Permalink

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  • Results of the study demonstrate that the circadian clock in the fetal rat suprachiasmatic nuclei develops gradually. At embryonic day 19 (E19), i.e., 4 days before delivery, the rhythms in expression of canonical clock genes Per2 and Bmal1 were absent and the clock developed just before birth. Expression of the clock gene Nr1d1 was rhythmic at E19 in absence of other clock gene expression rhythms and was thus likely driven by maternal cues instead of the core clockwork. The result suggest a molecular mechanism of how the rhythmic maternal cues entrain the developing fetal clock in the suprachiasmatic nuclei in vivo
  • Results of the study demonstrate that the circadian clock in the fetal rat suprachiasmatic nuclei develops gradually. At embryonic day 19 (E19), i.e., 4 days before delivery, the rhythms in expression of canonical clock genes Per2 and Bmal1 were absent and the clock developed just before birth. Expression of the clock gene Nr1d1 was rhythmic at E19 in absence of other clock gene expression rhythms and was thus likely driven by maternal cues instead of the core clockwork. The result suggest a molecular mechanism of how the rhythmic maternal cues entrain the developing fetal clock in the suprachiasmatic nuclei in vivo (en)
Title
  • In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei
  • In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei (en)
skos:prefLabel
  • In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei
  • In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei (en)
skos:notation
  • RIV/67985823:_____/14:00434397!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GAP303/12/1108)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 21090
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/14:00434397
http://linked.open...riv/jazykVysledku
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  • circadian; suprachiasmatic nuclei; ontogenesis; clock gene; entrainment; rat (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [54618A30EE74]
http://linked.open...i/riv/nazevZdroje
  • PLoS ONE
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 9
http://linked.open...iv/tvurceVysledku
  • Sumová, Alena
  • Houdek, Pavel
http://linked.open...ain/vavai/riv/wos
  • 000344862300022
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0107360
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