About: Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction

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About: Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the current study, we investigated the metabolic and hemodynamic effects of the SHR versus F344 mtDNA by comparing the SHR versus SHR-mtF344 conplastic strains that are genetically identical except for their mitochondrial genomes. Altogether 13 amino acid substitutions in protein coding genes, 7 single nucleotide polymorphisms in tRNA genes and 12 single nucleotide changes in rRNA genes were detected in F344 mtDNA when compared to SHR mtDNA. Analysis of oxidative phosphorylation system (OXPHOS) in heart left ventricles (LV), muscle and liver revealed reduced activity and content of several respiratory chain complexes in SHR-mtF344 conplastic rats when compared to the SHR strain. Lower function of OXPHOS in LV of conplastic rats was associated with significantly increased relative ventricular mass and reduced fractional shortening which was independent of blood pressure In the current study, we investigated the metabolic and hemodynamic effects of the SHR versus F344 mtDNA by comparing the SHR versus SHR-mtF344 conplastic strains that are genetically identical except for their mitochondrial genomes. Altogether 13 amino acid substitutions in protein coding genes, 7 single nucleotide polymorphisms in tRNA genes and 12 single nucleotide changes in rRNA genes were detected in F344 mtDNA when compared to SHR mtDNA. Analysis of oxidative phosphorylation system (OXPHOS) in heart left ventricles (LV), muscle and liver revealed reduced activity and content of several respiratory chain complexes in SHR-mtF344 conplastic rats when compared to the SHR strain. Lower function of OXPHOS in LV of conplastic rats was associated with significantly increased relative ventricular mass and reduced fractional shortening which was independent of blood pressure (en)
Title	Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction (en)
skos:prefLabel	Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction (en)
skos:notation	RIV/67985823:_____/14:00433305!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E10067), P(GA13-10267S), P(GB14-36804G), P(LL1204)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Papoušek, František Šilhavý, Jan Kolář, František Zídek, Václav Mlejnek, Petr Šimáková, Miroslava Landa, Vladimír Pravenec, Michal Mikšík, Ivan Houštěk, Josef Hejzlarová, Kateřina Vrbacký, Marek Neckář, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	13750
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00433305
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SHR conplastic strain with F344 mtDNA; impaired glucose tolerance; systolic dysfunction (en)
http://linked.open.../riv/klicoveSlovo	SHR conplastic strain with F344 mtDNA impaired glucose tolerance systolic dysfunction
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C7FB8D3A3046]
http://linked.open...i/riv/nazevZdroje	Physiological Genomics
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	13 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Ischemická tolerance srdcí spontánně hypertenzních potkanů: význam mitochondriálního genomu European large-scale functional genomics in the rat for translational research Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat Centrum mitochondriální biologie a patologie (MITOCENTRUM)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Kazdová, L. Kurtz, T. W. Landa, Vladimír Mlejnek, Petr Neckář, Jan Pravenec, Michal Zídek, Václav Šimáková, Miroslava Kolář, František Mikšík, Ivan Houštěk, Josef Vrbacký, Marek Šilhavý, Jan Hejzlarová, Kateřina Papoušek, František
http://linked.open...ain/vavai/riv/wos	000341705900001
issn	1094-8341
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1152/physiolgenomics.00069.2014

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