About: Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We demonstrate that methoctramine high affinity binding to the M2 receptors involves simultaneous interaction with both the orthosteric binding site and the allosteric binding site located between the second and third extracellular loops. Lysine 523 in the third extracellular loop of the M3 receptors forms a hydrogen bond with glutamate 219 of the second extracellular loop that hinders methoctramine binding to the allosteric site at this receptor subtype and results in low affinity of M3 receptor for methoctramine We demonstrate that methoctramine high affinity binding to the M2 receptors involves simultaneous interaction with both the orthosteric binding site and the allosteric binding site located between the second and third extracellular loops. Lysine 523 in the third extracellular loop of the M3 receptors forms a hydrogen bond with glutamate 219 of the second extracellular loop that hinders methoctramine binding to the allosteric site at this receptor subtype and results in low affinity of M3 receptor for methoctramine (en)
Title	Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors (en)
skos:prefLabel	Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors (en)
skos:notation	RIV/67985823:_____/14:00431597!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA305/09/0681), P(GAP304/12/0259), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zimčík, Pavel Doležal, Vladimír Jakubík, Jan Randáková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	30294
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00431597
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	muscarinic receptors; selectivity; methoctramine; allosteric; FRET (en)
http://linked.open.../riv/klicoveSlovo	allosteric methoctramine FRET muscarinic receptors selectivity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7D46B1C2A7CC]
http://linked.open...i/riv/nazevZdroje	Molecular Pharmacology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Mutual interactions of various vasoactive systems, reactive oxygen species and G proteins in experimental hypertension Molecular mechanisms of functional selectivity of atypical agonists at muscarinic receptors
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	86
http://linked.open...iv/tvurceVysledku	Doležal, Vladimír El-Fakahany, E. E. Jakubík, Jan Randáková, Alena Zimčík, Pavel Fuksová, Květoslava
http://linked.open...ain/vavai/riv/wos	000339267500006
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0026-895X
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1124/mol.114.093310

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